Medikamente
AMLODIPINE BESYLATE
Ãœberblick
Amlodipine Besylate is a medication often used to treat high blood pressure and chest pain. It belongs to a group of drugs known as calcium channel blockers, which work by relaxing blood vessels, allowing blood to flow more easily. This can help prevent strokes, heart attacks, and kidney problems. It's typically taken orally once a day, with or without food. Side effects can include swelling, dizziness, and flushing, but these are usually mild and temporary.
Kurzüberblick
Anwendungsgebiete & Verwendung
Wechselwirkungen mit anderen Medikamenten
Amlodipine Besylate can interact with various other medications, potentially altering their effectiveness or increasing side effects. For instance, when combined with certain heart medications, it may lower blood pressure too much, leading to dizziness or fainting. Additionally, combining it with grapefruit juice can increase the amount of the drug in your bloodstream, potentially leading to more side effects.
Nebenwirkungen
Genetische Einflüsse
The effectiveness and potential side effects of Amlodipine Besylate, a medication for high blood pressure and heart conditions, can be influenced by specific genetic factors. Genes such as CYP3A4 and CYP3A5, which are involved in the metabolism of the medication, and SLCO1B1, which is responsible for the uptake of the drug into the liver, play a crucial role. Variations in these genes can affect how the body processes and absorbs the medication, thereby impacting the required dosage and the likelihood of side effects.
Genetische Einflüsse
Amlodipine Besylate is a medication used to treat high blood pressure and heart-related conditions. Its effectiveness and the occurrence of side effects can be influenced by certain genetic factors. These genetic factors can affect how an individual's body processes the medication, which can impact the dosage required and the likelihood of experiencing side effects. Here are some of the key genes that play a role in this process.
CYP3A4: This gene codes for an enzyme involved in the metabolism of Amlodipine Besylate. Variations in this gene can affect how quickly the body breaks down the medication. This can influence the dosage needed and the risk of side effects.
CYP3A5: This is another gene involved in the metabolism of Amlodipine Besylate. Different versions of this gene can affect how the body processes the medication, which can impact its effectiveness and the potential for side effects.
SLCO1B1: This gene codes for a protein responsible for the uptake of Amlodipine Besylate into the liver. Variations in this gene can affect how much of the medication is absorbed by the body, influencing its effectiveness and the risk of side effects.
Es ist für Gesundheitsdienstleister wesentlich, individuelle Patientenfaktoren zu berücksichtigen und ihre spezifischen genetischen Profile zu verstehen, um personalisierte Behandlungsentscheidungen mit AMLODIPINE BESYLATE zu treffen.
Varianten, die AMLODIPINE BESYLATE beeinflussen
Gene, die AMLODIPINE BESYLATE beeinflussen
Dr. Wallerstorfer
Anzeige & Verwendung
Amlodipine Besylate is primarily used in the treatment of two common heart-related conditions: high blood pressure and chest pain, often referred to as angina. By lowering high blood pressure, it helps prevent strokes, heart attacks, and kidney problems. In cases of angina, it works to increase the ability of the heart to receive blood and oxygen, thereby reducing the frequency of angina attacks. It is important to note that while it improves the symptoms of these conditions, it does not cure them. It is also not intended for immediate relief during an acute angina attack.
Verwendung von AMLODIPINE BESYLATE
Amlodipine Besylate is primarily used to treat two common conditions related to the heart and blood vessels. The first is high blood pressure, where it helps to lower the pressure, making it easier for the heart to pump blood. The second is a type of chest pain called angina, where it improves blood flow to the heart muscle, helping to alleviate discomfort. It operates by relaxing the walls of the blood vessels, allowing for smoother and more efficient blood flow. Despite its benefits, it's important to note that it doesn't cure these conditions, but rather helps manage their symptoms.
Wann nicht AMLODIPINE BESYLATE verwenden
Amlodipine Besylate should be used with caution in individuals with certain health conditions. Those with severe heart conditions, particularly those who have recently experienced a heart attack, may need to avoid this medication. Similarly, individuals with low blood pressure or those who are prone to fluid build-up in the lungs may require lower doses. Liver problems can also affect how this medication is processed in the body, potentially necessitating a dosage adjustment. Lastly, pregnant or breastfeeding individuals should consult their healthcare provider before using this medication, as its effects on the developing fetus or nursing infant are not fully known.
Lagerung von AMLODIPINE BESYLATE
Amlodipine Besylate should be stored in a cool, dry place, away from direct sunlight and heat. It is recommended to keep it at room temperature, typically between 20°C to 25°C. For transportation, it should be kept in its original packaging to protect it from light and moisture. It's important to ensure that the medication is not exposed to extreme temperatures during transit. Lastly, it should always be kept out of reach of children and pets to prevent accidental ingestion.
Nebenwirkungen
Amlodipine Besylate, a commonly prescribed medication, can cause a range of side effects. These can vary from mild to severe, and not everyone who takes the medication will experience them. It's important to note that the benefits of taking this medication usually outweigh the potential side effects. However, it's crucial to be aware of what these side effects might be. The following list provides an overview of the most common side effects associated with Amlodipine Besylate.
Swelling: Particularly in the ankles and feet, this is a common side effect due to fluid build-up in the body, a condition known as edema.
Dizziness: This can occur as a result of taking the medication. It is often because the medication can lower blood pressure, which may cause light-headedness.
Flushing: Or a feeling of warmth and redness in the face, this is another possible side effect. It is typically harmless and usually subsides over time.
Headache: These are a common side effect of the medication. While usually mild, if they persist or become severe, medical advice should be sought.
Fatigue: Or feeling unusually tired can occur when taking the medication. This is because the medication can slow the heart rate, leading to feelings of tiredness.
Historischer Hintergrund
Amlodipine Besylate was first developed in the 1980s by the pharmaceutical company Pfizer. It was initially created as a new type of medication to help manage high blood pressure, a common health issue affecting millions worldwide. The drug was designed to work by relaxing the blood vessels, allowing blood to flow more easily and reducing the strain on the heart. After extensive testing and clinical trials, Amlodipine Besylate was approved by the U.S. Food and Drug Administration (FDA) in 1992. Since then, it has become a widely prescribed medication in many countries around the world. Over the years, it has also been found to be effective in treating other conditions such as certain types of chest pain (angina). Despite its success, like all medications, Amlodipine Besylate can have side effects, which led to further research to improve its safety profile. Today, it continues to be a crucial tool in the management of cardiovascular diseases.