Genetic variation
19:g.6668961C>G
This variation affects:
Overview
19:g.6668961C>G is a genetic variant on gene TNFSF14 associated with Multiple sclerosis.
This variant is located on chromosome 19. The variations at position 6668961 are the genetic letters C/C, G/G, T/T, C/G, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant 19:g.6668961C>G there are 5 currently known genotypes : C/C, G/G, T/T, C/G or C/T
Short Overview
Variant Location
19:g.6668961C>G is located on gene TNFSF14 in chromsome 19. Use the genome browser to explore the location of 19:g.6668961C>G and its genetic neighbourhood.
Pharmacogenetics
19:g.6668961C>G affects the following drugs:
Diagnostics
19:g.6668961C>G is commonly tested together with other variants on the same gene.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant on gene TNFSF14. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are random changes in the DNA and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Dr. Wallerstorfer
Conditions & Traits of 19:g.6668961C>G
The different genotypes of variant 19:g.6668961C>G can affect the expression or likelyhood of developing certain traits or conditions. Current research shows that 1 condition and 0 traits are associated with 19:g.6668961C>G. The following table shows the relationship between genotypes and conditions and traits.
Did you know genetic variants affect drugs?
Genetic variants can influence how our body reacts to certain drugs. The presence of specific genetic variants can increase or decrease the efficiency and effectiveness of a drug, impacting how well it works inside our system. Additionally, certain genetic variants can heighten or lessen the toxicity of a drug, thereby affecting the risk of unwanted side effects. They can also alter how a drug is metabolized, which influences the appropriate dosage one should receive.
Dr. Wallerstorfer
Variant Classification based on Scientific Studies
Scientific studies classifications aim to uncover how genetic variants function and their roles in diseases, traits, and evolution. Variants are categorized based on their functional impact, such as loss-of-function (reduces gene activity), gain-of-function (increases gene activity), neutral (no significant impact), or evolutionary conservation. This classification uses experimental data, population studies, and computational analyses to understand variant effects. Unlike clinical testing, which focuses on immediate health impacts, scientific studies explore broader genetic mechanisms and long-term implications.
Genotype
C
C
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
G
G
Level of evidence
Increased likelihood
Unisex
1 Sources
Participants: 38589
The genotype with the letters G/G is considered a risk factor for developing the disease. Carriers of this genetic result are at increased risk of developing the disease.
Genotype
C
G
Level of evidence
Increased likelihood
Unisex
2 Sources
Participants: 80094
The genotype with the letters C/G is considered a risk factor for developing the disease. Carriers of this genetic result are at increased risk of developing the disease.
Genotype
C
T
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
C
C
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
G
G
Level of evidence
Increased likelihood
Unisex
1 Sources
Participants: 38589
The genotype with the letters G/G is considered a risk factor for developing the disease. Carriers of this genetic result are at increased risk of developing the disease.
Genotype
C
G
Level of evidence
Increased likelihood
Unisex
2 Sources
Participants: 80094
The genotype with the letters C/G is considered a risk factor for developing the disease. Carriers of this genetic result are at increased risk of developing the disease.
Genotype
C
T
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Pharmacogenetics
The genetic variant 19:g.6668961C>G impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with 19:g.6668961C>G. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Drugs related to 19:g.6668961C>G
All drugs that are linked to 19:g.6668961C>G are listed here.
Diagnostics
19:g.6668961C>G is commonly tested together with other variants on the same gene.
Related variants
Conditions and traits are often affected by more than one variant. It is important to understand these other factors to get a better understanding of how genetics affect certain conditions and traits. The following grid shows other variants that affect the same conditions and traits as 19:g.6668961C>G.
Genotype Distribution
Knowing your genome can actually tell you a lot about your ancestors.
The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.
This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.
At present, there is no distribution data available for SNP 1077667. 1077667.
Studies and Sources
All of the resources below examine variant
William J Astle, Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Alice L Mann, Daniel Mead, Heleen Bouman, Fernando Riveros-Mckay, Myrto A Kostadima, John J Lambourne, Suthesh Sivapalaratnam, Kate Downes, Kousik Kundu, Lorenzo Bomba, Kim Berentsen, John R Bradley, Louise C Daugherty, Olivier Delaneau, Kathleen Freson, Stephen F Garner, Luigi Grassi, Jose Guerrero, Matthias Haimel, Eva M Janssen-Megens, Anita Kaan, Mihir Kamat, Bowon Kim, Amit Mandoli, Jonathan Marchini, Joost H A Martens, Stuart Meacham, Karyn Megy, Jared O'Connell, Romina Petersen, Nilofar Sharifi, Simon M Sheard, James R Staley, Salih Tuna, Martijn van der Ent, Klaudia Walter, Shuang-Yin Wang, Eleanor Wheeler, Steven P Wilder, Valentina Iotchkova, Carmel Moore, Jennifer Sambrook, Hendrik G Stunnenberg, Emanuele Di Angelantonio, Stephen Kaptoge, Taco W Kuijpers, Enrique Carrillo-de-Santa-Pau, David Juan, Daniel Rico, Alfonso Valencia, Lu Chen, Bing Ge, Louella Vasquez, Tony Kwan, Diego Garrido-Martín, Stephen Watt, Ying Yang, Roderic Guigo, Stephan Beck, Dirk S Paul, Tomi Pastinen, David Bujold, Guillaume Bourque, Mattia Frontini, John Danesh, David J Roberts, Willem H Ouwehand, Adam S Butterworth, Nicole Soranzo