The effectiveness and side effects of Aspirin can be influenced by certain genetic factors. These factors can affect how an individual metabolizes the drug, their susceptibility to side effects, and even the dosage required for effective treatment. It's important to note that these genetic influences do not determine an individual's response to Aspirin, but they can play a significant role.
CYP2C9: This gene is involved in the metabolism of Aspirin. Variations can lead to differences in how quickly the body breaks down and eliminates the drug. This can influence the drug's effectiveness and the likelihood of experiencing side effects.
UGT1A6: This gene also plays a role in the metabolism of Aspirin. Certain genetic variants can slow down this process, potentially leading to higher levels of the drug in the body and an increased risk of side effects.
ABCB1: This gene influences the transport of Aspirin within the body. Variations can affect how much of the drug reaches its target sites, potentially impacting its effectiveness.
rs4291
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
rs4292
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
rs5918
located on ITGB3 gene
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect to ASPIRIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have decreased Drug Effect to ASPIRIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Drug Effect to ASPIRIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
rs4291
Genotype
Level of evidence
Effect
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
rs4292
Genotype
Level of evidence
Effect
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
rs5918
located on ITGB3 gene
Genotype
Level of evidence
Effect
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect to ASPIRIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have decreased Drug Effect to ASPIRIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Drug Effect to ASPIRIN.
more info
Legend:
Increased
Decreased
No known effect
It is essential for healthcare providers to consider individual patient factors and understand their specific genetic profiles to make personalized treatment decisions with ASPIRIN