Lisinopril is a medication often prescribed to treat high blood pressure and heart failure. It works by relaxing blood vessels, allowing blood to flow more easily, which helps lower blood pressure and reduce the strain on the heart. This drug is also used to improve survival after a heart attack. Lisinopril belongs to a class of drugs known as ACE inhibitors. Common side effects may include dizziness, lightheadedness, or tiredness.

Short Overview

Indications & Usage

High blood pressureHeart attack recoveryHeart failureKidney problems in people with diabetes

Interactions with other Drugs

Lisinopril can interact with other medications, altering their effectiveness or increasing side effects. Particularly, when combined with drugs like potassium supplements, diuretics, or certain diabetes medications, it can lead to dangerously high potassium levels. Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce Lisinopril's ability to lower blood pressure.

Side Effects

Dizziness and lightheadednessDry coughHeadacheRashKidney problems

Genetic Influences

Lisinopril's effectiveness and dosage can be influenced by variations in the ACE gene, which produces an enzyme that affects blood pressure. The ADD1 gene, involved in blood pressure regulation, can also affect a person's response to Lisinopril, with some gene variations leading to better blood pressure control. The AGTR1 gene, another regulator of blood pressure, can impact the likelihood of side effects from Lisinopril, necessitating closer monitoring for individuals with certain variations.

Genetic Influences

Lisinopril, a medication used to treat high blood pressure and heart failure, interacts with certain genes in our body. These genes can influence how well the medication works, how it's dosed, and who can take it. Additionally, they can also affect the likelihood of experiencing side effects. Understanding these genetic influences can help healthcare providers personalize treatment plans for optimal effectiveness and minimal side effects.

  • ACE Gene: This gene produces an enzyme that affects blood pressure. Variations in it can influence how well Lisinopril works. Some people with certain variations may need a higher or lower dose for the medication to be effective.

  • ADD1 Gene: This gene is involved in regulating blood pressure. Variations in it can affect how a person responds to Lisinopril. Some people may experience better blood pressure control with Lisinopril due to their gene variation.

  • AGTR1 Gene: This gene plays a role in blood pressure regulation. Certain variations in it can influence the likelihood of experiencing side effects from Lisinopril. People with these variations may need to be monitored more closely for side effects.

rs4291

Genotype
AA
Impacts

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Drug Effect

Side Effects

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Summary

No summary available.

Level of evidence

More info

Genotype
AT
Impacts

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Dosage

Summary

No summary available.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

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Dosage

Summary

No summary available.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

rs1799722

Genotype
CC
Impacts

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Drug Effect

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Summary

No summary available.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

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Dosage

Summary

Individuals with the genotype C/T have increased Side Effects to LISINOPRIL.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Side Effects to LISINOPRIL.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

rs1799752

Genotype
--
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype -/- have decreased Drug Effect to LISINOPRIL.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

rs4291

Genotype
Level of evidence
Effect
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

AT

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

Legend:

Increased

Decreased

No known effect

rs1799722

Genotype
Level of evidence
Effect
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Side Effects to LISINOPRIL.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Side Effects to LISINOPRIL.

more info

Legend:

Increased

Decreased

No known effect

rs1799752

Genotype
Level of evidence
Effect
Summary
--

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype -/- have decreased Drug Effect to LISINOPRIL.

more info

Legend:

Increased

Decreased

No known effect

It is essential for healthcare providers to consider individual patient factors and understand their specific genetic profiles to make personalized treatment decisions with LISINOPRIL

Dr. Wallerstorfer Dr. Wallerstorfer

Indication & Usage

Lisinopril is primarily used to treat high blood pressure, a condition that can lead to serious heart problems if left unchecked. It is also beneficial for individuals who have suffered a heart attack, as it aids in the recovery process by reducing strain on the heart. Additionally, it is prescribed for heart failure, a condition where the heart can't pump blood as well as it should. In some cases, Lisinopril is used to treat kidney problems in people with diabetes, helping to protect the kidneys from further damage. Despite its wide range of uses, it's important to note that Lisinopril is a part of a comprehensive treatment plan that may include diet, exercise, and other medications.

Usage of LISINOPRIL

Lisinopril is primarily used in the treatment of high blood pressure, a condition that can lead to serious heart problems if left unchecked. It is also beneficial for individuals who have suffered a heart attack, as it aids in the recovery process by reducing the strain on the heart. Additionally, it is used to treat kidney complications in people with diabetes, helping to slow down the progression of kidney disease. Lisinopril works by relaxing blood vessels, allowing blood to flow more easily, thereby lowering blood pressure and reducing the heart's workload. Despite its benefits, it's important to note that Lisinopril may cause side effects such as dizziness or lightheadedness, especially in the early stages of treatment.

When not to use LISINOPRIL

Lisinopril should be used with caution in individuals with kidney problems, as it may further impair kidney function. Those with liver disease may also require careful monitoring or reduced dosages, as the drug is processed in the liver. Pregnant women should avoid Lisinopril due to potential harm to the fetus. Additionally, individuals with a history of angioedema, a type of swelling, should not use this medication. Lastly, those with low blood pressure or who are dehydrated may need to avoid or adjust their use of Lisinopril, as it can lower blood pressure further.

Storage of LISINOPRIL

Lisinopril should be stored in a cool, dry place, away from direct sunlight and heat. It is important to keep it in its original container, tightly closed, and out of reach of children. For transportation, it should be kept at room temperature, avoiding extreme conditions such as freezing or high heat. It is not necessary to refrigerate Lisinopril. In case of accidental spillage or damage, professional medical waste disposal services should be contacted.

Side Effects

Lisinopril, a medication used to treat high blood pressure and heart failure, can have several side effects. These side effects can range from mild to severe, and not everyone who takes the medication will experience them. It's important to note that the benefits of taking Lisinopril usually outweigh the potential side effects. However, it's crucial to be aware of these possible side effects and to seek medical attention if they occur.

  • Dizziness and lightheadedness: This is often due to a drop in blood pressure, especially when standing up from a sitting or lying position.

  • Dry cough: This is due to the medication's effect on the lungs, and it usually resolves once the medication is stopped.

  • Headache: While usually mild, they can be bothersome and may require treatment with over-the-counter pain relievers.

  • Rash: This can range from a mild, itchy rash to a more severe reaction with hives and swelling.

  • Kidney problems: This is usually detected through routine blood tests and may require a change in medication.

Historical Perspective

Lisinopril, a medication used primarily for treating high blood pressure and heart failure, has an interesting history. It was developed in the 1970s by scientists at Merck and Co., a pharmaceutical company. The drug was created as part of a larger group of medications known as angiotensin-converting enzyme (ACE) inhibitors. The goal was to develop a drug that could help manage blood pressure and reduce the strain on the heart. Lisinopril was first approved for medical use in the United States in 1987. Since then, it has become one of the most commonly prescribed medications for hypertension and heart conditions. It's also used to prevent kidney complications in people with diabetes. Over the years, numerous studies have confirmed its effectiveness and safety, making it a staple in modern medicine.

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