Genetic variation
rs74375025
This variation affects:
Other names:
Overview
rs74375025 is a genetic variant associated with Proteinuria.
This variant is located on chromosome 10. The variations at position 16905665 are the genetic letters A/A, A/G
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs74375025 there are 2 currently known genotypes : A/A or A/G
Short Overview
Variant Location
rs74375025 is located on gene in chromsome 10. Use the genome browser to explore the location of rs74375025 and its genetic neighbourhood.
Pharmacogenetics
We do not have any data that links rs74375025 to any drugs.
Diagnostics
rs74375025 is commonly tested together with other variants on the same gene.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are random changes in the DNA and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Dr. Wallerstorfer
Conditions & Traits of rs74375025
The different genotypes of variant rs74375025 can affect the expression or likelyhood of developing certain traits or conditions. Current research shows that 1 condition and 0 traits are associated with rs74375025. The following table shows the relationship between genotypes and conditions and traits.
Did you know genetic variants affect drugs?
Genetic variants can influence how our body reacts to certain drugs. The presence of specific genetic variants can increase or decrease the efficiency and effectiveness of a drug, impacting how well it works inside our system. Additionally, certain genetic variants can heighten or lessen the toxicity of a drug, thereby affecting the risk of unwanted side effects. They can also alter how a drug is metabolized, which influences the appropriate dosage one should receive.
Dr. Wallerstorfer
Variant Table Legend
Clinical Testing
Scientific Studies
Biological Male Symbol
Biological Female Symbol
Unisex Symbol for both Genders
Variant Classification based on Scientific Studies
Scientific studies classifications aim to uncover how genetic variants function and their roles in diseases, traits, and evolution. Variants are categorized based on their functional impact, such as loss-of-function (reduces gene activity), gain-of-function (increases gene activity), neutral (no significant impact), or evolutionary conservation. This classification uses experimental data, population studies, and computational analyses to understand variant effects. Unlike clinical testing, which focuses on immediate health impacts, scientific studies explore broader genetic mechanisms and long-term implications.
Genotype
A
A
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
A
G
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
A
A
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Genotype
A
G
Level of evidence
No Effect
Unisex
0 Sources
Participants: 0
No available data
Pharmacogenetics
The genetic variant rs74375025 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs74375025. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Drugs related to rs74375025
All drugs that are linked to rs74375025 are listed here.
Diagnostics
rs74375025 is commonly tested together with other variants on the same gene.
Related variants
Conditions and traits are often affected by more than one variant. It is important to understand these other factors to get a better understanding of how genetics affect certain conditions and traits. The following grid shows other variants that affect the same conditions and traits as rs74375025.
Genotype Distribution
Knowing your genome can actually tell you a lot about your ancestors.
The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.
This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.
At present, there is no distribution data available for SNP 74375025. 74375025.
Studies and Sources
All of the resources below examine variant rs
Stefania Benonisdottir, Ragnar P Kristjansson, Asmundur Oddsson, Valgerdur Steinthorsdottir, Evgenia Mikaelsdottir, Birte Kehr, Brynjar O Jensson, Gudny A Arnadottir, Gerald Sulem, Gardar Sveinbjornsson, Snaedis Kristmundsdottir, Erna V Ivarsdottir, Vinicius Tragante, Bjarni Gunnarsson, Hrafnhildur Linnet Runolfsdottir, Joseph G Arthur, Aimee M Deaton, Gudmundur I Eyjolfsson, Olafur B Davidsson, Folkert W Asselbergs, Astradur B Hreidarsson, Thorunn Rafnar, Gudmar Thorleifsson, Vidar Edvardsson, Gunnar Sigurdsson, Anna Helgadottir, Bjarni V Halldorsson, Gisli Masson, Hilma Holm, Pall T Onundarson, Olafur S Indridason, Rafn Benediktsson, Runolfur Palsson, Daniel F Gudbjartsson, Isleifur Olafsson, Unnur Thorsteinsdottir, Patrick Sulem, Kari Stefansson
Alexander Teumer, Yong Li, Sahar Ghasemi, Bram P Prins, Matthias Wuttke, Tobias Hermle, Ayush Giri, Karsten B Sieber, Chengxiang Qiu, Holger Kirsten, Adrienne Tin, Audrey Y Chu, Nisha Bansal, Mary F Feitosa, Lihua Wang, Jin-Fang Chai, Massimiliano Cocca, Christian Fuchsberger, Mathias Gorski, Anselm Hoppmann, Katrin Horn, Man Li, Jonathan Marten, Damia Noce, Teresa Nutile, Sanaz Sedaghat, Gardar Sveinbjornsson, Bamidele O Tayo, Peter J van der Most, Yizhe Xu, Zhi Yu, Lea Gerstner, Johan Ärnlöv, Stephan J L Bakker, Daniela Baptista, Mary L Biggs, Eric Boerwinkle, Hermann Brenner, Ralph Burkhardt, Robert J Carroll, Miao-Li Chee, Miao-Ling Chee, Mengmeng Chen, Ching-Yu Cheng, James P Cook, Josef Coresh, Tanguy Corre, John Danesh, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko P J de Vries, Frauke Degenhardt, Katalin Dittrich, Jasmin Divers, Kai-Uwe Eckardt, Georg Ehret, Karlhans Endlich, Janine F Felix, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Ron T Gansevoort, Vilmantas Giedraitis, Martin Gögele, Franziska Grundner-Culemann, Daniel F Gudbjartsson, Vilmundur Gudnason, Pavel Hamet, Tamara B Harris, Andrew A Hicks, Hilma Holm, Valencia Hui Xian Foo, Shih-Jen Hwang, M Arfan Ikram, Erik Ingelsson, Vincent W V Jaddoe, Johanna Jakobsdottir, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Chiea-Chuen Khor, Wieland Kiess, Wolfgang Koenig, Antje Körner, Peter Kovacs, Holly Kramer, Bernhard K Krämer, Florian Kronenberg, Leslie A Lange, Carl D Langefeld, Jeannette Jen-Mai Lee, Terho Lehtimäki, Wolfgang Lieb, Su-Chi Lim, Lars Lind, Cecilia M Lindgren, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Anubha Mahajan, Joseph C Maranville, Deborah Mascalzoni, Barbara McMullen, Christa Meisinger, Thomas Meitinger, Kozeta Miliku, Dennis O Mook-Kanamori, Martina Müller-Nurasyid, Josyf C Mychaleckyj, Matthias Nauck, Kjell Nikus, Boting Ning, Raymond Noordam, Jeffrey O' Connell, Isleifur Olafsson, Nicholette D Palmer, Annette Peters, Anna I Podgornaia, Belen Ponte, Tanja Poulain, Peter P Pramstaller, Ton J Rabelink, Laura M Raffield, Dermot F Reilly, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Fernando Rivadeneira, Heiko Runz, Kathleen A Ryan, Charumathi Sabanayagam, Kai-Uwe Saum, Ben Schöttker, Christian M Shaffer, Yuan Shi, Albert V Smith, Konstantin Strauch, Michael Stumvoll, Benjamin B Sun, Silke Szymczak, E-Shyong Tai, Nicholas Y Q Tan, Kent D Taylor, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Hauke Thomsen, Unnur Thorsteinsdottir, Anke Tönjes, Johanne Tremblay, André G Uitterlinden, Pim van der Harst, Niek Verweij, Suzanne Vogelezang, Uwe Völker, Melanie Waldenberger, Chaolong Wang, Otis D Wilson, Charlene Wong, Tien-Yin Wong, Qiong Yang, Masayuki Yasuda, Shreeram Akilesh, Murielle Bochud, Carsten A Böger, Olivier Devuyst, Todd L Edwards, Kevin Ho, Andrew P Morris, Afshin Parsa, Sarah A Pendergrass, Bruce M Psaty, Jerome I Rotter, Kari Stefansson, James G Wilson, Katalin Susztak, Harold Snieder, Iris M Heid, Markus Scholz, Adam S Butterworth, Adriana M Hung, Cristian Pattaro, Anna Köttgen