Overview

rs11177 is a genetic variant on gene GNL3.

This variant is located on chromosome 3. The variations at position 52687289 are the genetic letters A/A, C/C, G/G, T/T, A/C, C/G, G/T, A/T, A/G, C/T

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs11177 there are 10 currently known genotypes : A/A, C/C, G/G, T/T, A/C, C/G, G/T, A/T, A/G or C/T

Short Overview

Variant Location

rs11177 is located on gene GNL3 in chromsome 3. Use the genome browser to explore the location of rs11177 and its genetic neighbourhood.

Conditions & Traits

rs11177 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs11177.

Pathogenicity

rs11177 affects the following conditions:

There are currently 0 conditions associated with rs11177.

Pharmacogenetics

We do not have any data that links rs11177 to any drugs.

Diagnostics

rs11177 is commonly tested together with other variants on the same gene.

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene GNL3. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer

Conditions & Traits of rs11177

Current research shows 0 conditions and 0 traits.

Diagnostics

rs11177 is commonly tested together with other variants on the same gene.

Genotype Distribution

Knowing your genome can actually tell you a lot about your ancestors.

The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.

This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.

At present, there is no distribution data available for SNP 11177. 11177.

The Genotype Distribution in the selected area is:
Legend:
Included regions
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no-data

Studies and Sources

All of the resources below examine variant rs11177

JEPEG: a summary statistics based tool for gene-level joint testing of functional variants (4/15/15)

Donghyung Lee, Vernell S. Williamson, T. Bernard Bigdeli, Brien P. Riley, Ayman H. Fanous, Vladimir I. Vladimirov, Silviu-Alin Bacanu

PMC: 4393522
Genome-wide Association and Functional Studies Identify a Role for IGFBP3 in Hip Osteoarthritis (5/16/15)

Daniel S. Evans, Frederic Cailotto, Neeta Parimi, Ana M. Valdes, Martha C. Castaño-Betancourt, Youfang Liu, Robert C. Kaplan, Martin Bidlingmaier, Ramachandran S. Vasan, Alexander Teumer, Gregory J. Tranah, Michael C. Nevitt, Steven R. Cummings, Eric S. Orwoll, Elizabeth Barrett-Connor, Jordan B. Renner, Joanne M. Jordan, Michael Doherty, Sally A. Doherty, Andre G. Uitterlinden, Joyce B.J. van Meurs, Tim D. Spector, Rik J. Lories, Nancy E. Lane

PMC: 4449305
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis (10/4/16)

Martha C. Castaño-Betancourt, Dan S. Evans, Yolande F. M. Ramos, Cindy G. Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B. Kraus, Michelle S. Yau, Braxton D. Mitchell, Kenneth Muir, Albert Hofman, Michael Doherty, Sally Doherty, Weiya Zhang, Robert Kraaij, Fernando Rivadeneira, Elizabeth Barrett-Connor, Rose A. Maciewicz, Nigel Arden, Rob G. H. H. Nelissen, Margreet Kloppenburg, Joanne M. Jordan, Michael C. Nevitt, Eline P. Slagboom, Deborah J. Hart, Floris Lafeber, Unnur Styrkarsdottir, Eleftheria Zeggini, Evangelos Evangelou, Tim D. Spector, Andre G. Uitterlinden, Nancy E. Lane, Ingrid Meulenbelt, Ana M. Valdes, Joyce B. J. van Meurs

PMC: 5049763
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