Overview

rs1042718 is a genetic variant on gene ADRB2.

This variant is located on chromosome 5. The variations at position 148827354 are the genetic letters A/A, C/C, A/C

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1042718 there are 3 currently known genotypes : A/A, C/C or A/C

Short Overview

Variant Location

rs1042718 is located on gene ADRB2 in chromsome 5. Use the genome browser to explore the location of rs1042718 and its genetic neighbourhood.

Conditions & Traits

rs1042718 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs1042718.

Pathogenicity

rs1042718 affects the following conditions:

There are currently 0 conditions associated with rs1042718.

Pharmacogenetics

rs1042718 affects the following drugs:

Diagnostics

rs1042718 is commonly tested together with other variants on the same gene.

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene ADRB2. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

Loading Genome Browser...

Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer

Conditions & Traits of rs1042718

Current research shows 0 conditions and 0 traits.

Pharmacogenetics

The genetic variant rs1042718 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1042718. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have increased Side Effects to FENTANYL.

more info

AC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/C have increased Side Effects to FENTANYL.

more info

CC

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have increased Side Effects to PROPOFOL.

more info

AC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/C have increased Side Effects to PROPOFOL.

more info

CC

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have increased Side Effects to SEVOFLURANE.

more info

AC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/C have increased Side Effects to SEVOFLURANE.

more info

CC

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have increased Side Effects to FENTANYL.

Level of evidence

More info

Genotype
AC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/C have increased Side Effects to FENTANYL.

Level of evidence

More info

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have increased Side Effects to PROPOFOL.

Level of evidence

More info

Genotype
AC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/C have increased Side Effects to PROPOFOL.

Level of evidence

More info

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have increased Side Effects to SEVOFLURANE.

Level of evidence

More info

Genotype
AC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/C have increased Side Effects to SEVOFLURANE.

Level of evidence

More info

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs1042718

All drugs that are linked to rs1042718 are listed here.

Diagnostics

rs1042718 is commonly tested together with other variants on the same gene.

Genotype Distribution

Knowing your genome can actually tell you a lot about your ancestors.

The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.

This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.

At present, there is no distribution data available for SNP 1042718. 1042718.

The Genotype Distribution in the selected area is:
Legend:
Included regions
Excluded regions
no-data

Studies and Sources

All of the resources below examine variant rs1042718

Association of COPD candidate genes with CT emphysema and airway phenotypes in severe COPD (2/22/11)

Woo Jin Kim, Eric Hoffman, John Reilly, Craig Hersh, Dawn DeMeo, George Washko, Edwin K. Silverman

PMC: 3074301
Variation in Genes that Regulate Blood Pressure Are Associated with Glomerular Filtration Rate in Chinese

May E. Montasser, Lawrence C. Shimmin, Dongfeng Gu, Jing Chen, Charles Gu, Tanika N. Kelly, Cashell E. Jaquish, Treva K. Rice, Dabeeru C. Rao, Jie Cao, Jichun Chen, De-Pei Liu, Paul K. Whelton, Lotuce Lee Hamm, Jiang He, James E. Hixson

PMC: 3962404
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