Overview

CYP2C19*32 is a specific haplotype found on the cytochrome P450 family 2 subfamily C member 19 gene.  This haplotype is intricately connected to 33 specific variants. It plays a significant role in how individuals metabolize certain drugs, especially voriconazole, tacrolimus, diazepam, clobazam, valproic acid, mephenytoin, dexlansoprazole, lansoprazole, progesterone, omeprazole, brivaracetam, carisoprodol, prasugrel. CYP2C19*32 has a Haplotype Performance of 100%. The combined haplotype performances of two haplotypes and individual posseses on cytochrome P450 family 2 subfamily C member 19 determines the overall gene performance. The gene performance indicates the metabolism rate, classifying individuals as either poor, intermediate, extensive, or ultrarapid metabolizers. This has a direct influence on how they process certain drugs.

Role of the Gene that carries the Haplotype CYP2C19*32

The gene cytochrome P450 family 2 subfamily C member 19, plays a crucial role in the way our body processes fat by breaking it down and managing its levels. This occurs mostly in the liver, an essential organ for maintaining healthy body functions. The gene can lead to a change in the protein structure, potentially causing inefficient breakdown of fat. This may contribute to an increased risk of developing liver-related health issues such as fatty liver disease. While genetics play a part, maintaining a healthy lifestyle can help minimize these risks.

CYP2C19*32

% Haplotype Performance:

100%

This is the standard or typical haplotype performance. The haplotype performance is at a "normal" level.

The haplotype performances of two haplotypes an individual possess on cytochrome P450 family 2 subfamily C member 19 determines their overall gene performance.

100% Haplotype Performance

The haplotype performance of a haplotype, when considering drug metabolization, provides a quantifiable measure of how effectively a person's genetics might influence their ability to metabolize or break down specific drugs. The combined effect of the two haplotypes you possess (i.e., the two sets of variants) will determine your overall gene performance related to drug metabolism.

Set of variants that define CYP2C19*32

Haplotypes are linked to multiple variants, and each variant in the haplotype has a specific allele.

there are 33 Variants linked to CYP2C19*32 in the databse:

CYP2C19*32

Variant
Allele
Summary

rs3758581

G

rs3758581 is a genetic variant on gene CYP2C19.

rs4244285

G

rs4244285 is a genetic variant on gene CYP2C19.

rs4986893

G

rs4986893 is a genetic variant on gene CYP2C19.

rs6413438

C

rs6413438 is a genetic variant on gene CYP2C19.

rs12248560

C

rs12248560 is a genetic variant.

rs12769205

A

rs12769205 is a genetic variant.

rs17879685

C

rs17879685 is a genetic variant on gene CYP2C19.

rs17882687

A

rs17882687 is a genetic variant on gene CYP2C19.

rs17884712

G

rs17884712 is a genetic variant on gene CYP2C19.

rs28399504

A

rs28399504 is a genetic variant on gene CYP2C19.

rs41291556

T

rs41291556 is a genetic variant on gene CYP2C19.

rs55640102

A

rs55640102 is a genetic variant on gene CYP2C19.

rs55752064

T

rs55752064 is a genetic variant on gene CYP2C19.

rs56337013

C

rs56337013 is a genetic variant on gene CYP2C19.

rs58973490

G

rs58973490 is a genetic variant on gene CYP2C19.

rs72552267

G

rs72552267 is a genetic variant on gene CYP2C19.

rs72558186

T

rs72558186 is a genetic variant.

rs113934938

G

rs113934938 is a genetic variant on gene CYP2C19.

rs118203756

G

rs118203756 is a genetic variant on gene CYP2C19.

rs118203757

G

rs118203757 is a genetic variant on gene CYP2C19.

rs118203759

C

rs118203759 is a genetic variant on gene CYP2C19.

rs138142612

G

rs138142612 is a genetic variant on gene CYP2C19.

rs140278421

G

rs140278421 is a genetic variant on gene CYP2C19.

rs145328984

C

rs145328984 is a genetic variant on gene CYP2C19.

rs192154563

C

rs192154563 is a genetic variant on gene CYP2C19.

rs367543002

C

rs367543002 is a genetic variant on gene CYP2C19.

rs367543003

T

rs367543003 is a genetic variant on gene CYP2C19.

rs370803989

G

rs370803989 is a genetic variant on gene CYP2C19.

rs375781227

G

rs375781227 is a genetic variant on gene CYP2C19.

rs1288601658

G

rs1288601658 is a genetic variant on gene CYP2C19.

rs1564656981

A

rs1564656981 is a genetic variant on gene CYP2C19.

rs1564657013

A

rs1564657013 is a genetic variant on gene CYP2C19.

rs1564660997

C

rs1564660997 is a genetic variant on gene CYP2C19.

CYP2C19*32

Name

rs3758581

Allele

G

Summary

rs3758581 is a genetic variant on gene CYP2C19.

Name

rs4244285

Allele

G

Summary

rs4244285 is a genetic variant on gene CYP2C19.

Name

rs4986893

Allele

G

Summary

rs4986893 is a genetic variant on gene CYP2C19.

Name

rs6413438

Allele

C

Summary

rs6413438 is a genetic variant on gene CYP2C19.

Name

rs12248560

Allele

C

Summary

rs12248560 is a genetic variant.

Name

rs12769205

Allele

A

Summary

rs12769205 is a genetic variant.

Name

rs17879685

Allele

C

Summary

rs17879685 is a genetic variant on gene CYP2C19.

Name

rs17882687

Allele

A

Summary

rs17882687 is a genetic variant on gene CYP2C19.

Name

rs17884712

Allele

G

Summary

rs17884712 is a genetic variant on gene CYP2C19.

Name

rs28399504

Allele

A

Summary

rs28399504 is a genetic variant on gene CYP2C19.

Name

rs41291556

Allele

T

Summary

rs41291556 is a genetic variant on gene CYP2C19.

Name

rs55640102

Allele

A

Summary

rs55640102 is a genetic variant on gene CYP2C19.

Name

rs55752064

Allele

T

Summary

rs55752064 is a genetic variant on gene CYP2C19.

Name

rs56337013

Allele

C

Summary

rs56337013 is a genetic variant on gene CYP2C19.

Name

rs58973490

Allele

G

Summary

rs58973490 is a genetic variant on gene CYP2C19.

Name

rs72552267

Allele

G

Summary

rs72552267 is a genetic variant on gene CYP2C19.

Name

rs72558186

Allele

T

Summary

rs72558186 is a genetic variant.

Name

rs113934938

Allele

G

Summary

rs113934938 is a genetic variant on gene CYP2C19.

Name

rs118203756

Allele

G

Summary

rs118203756 is a genetic variant on gene CYP2C19.

Name

rs118203757

Allele

G

Summary

rs118203757 is a genetic variant on gene CYP2C19.

Name

rs118203759

Allele

C

Summary

rs118203759 is a genetic variant on gene CYP2C19.

Name

rs138142612

Allele

G

Summary

rs138142612 is a genetic variant on gene CYP2C19.

Name

rs140278421

Allele

G

Summary

rs140278421 is a genetic variant on gene CYP2C19.

Name

rs145328984

Allele

C

Summary

rs145328984 is a genetic variant on gene CYP2C19.

Name

rs192154563

Allele

C

Summary

rs192154563 is a genetic variant on gene CYP2C19.

Name

rs367543002

Allele

C

Summary

rs367543002 is a genetic variant on gene CYP2C19.

Name

rs367543003

Allele

T

Summary

rs367543003 is a genetic variant on gene CYP2C19.

Name

rs370803989

Allele

G

Summary

rs370803989 is a genetic variant on gene CYP2C19.

Name

rs375781227

Allele

G

Summary

rs375781227 is a genetic variant on gene CYP2C19.

Name

rs1288601658

Allele

G

Summary

rs1288601658 is a genetic variant on gene CYP2C19.

Name

rs1564656981

Allele

A

Summary

rs1564656981 is a genetic variant on gene CYP2C19.

Name

rs1564657013

Allele

A

Summary

rs1564657013 is a genetic variant on gene CYP2C19.

Name

rs1564660997

Allele

C

Summary

rs1564660997 is a genetic variant on gene CYP2C19.

Did you know that haplotypes play a major role in pharmacogenetics?

Certain haplotypes in combination can influence how a person's body metabolizes drugs. This is because these haplotypes can affect the function of enzymes responsible for drug metabolism. A change or variation in the DNA sequence of a gene that codes for a drug-metabolizing enzyme can increase or decrease the activity of that enzyme.

Based on the activity of these enzymes (influenced by haplotypes), individuals can be classified into different metabolizer categories:

  1. Poor Metabolizers (PMs): These individuals have little or no enzyme activity due to certain genetic variations. As a result, they might not metabolize certain drugs efficiently, leading to a higher risk of side effects because the drug remains in their system for a longer time.
  2. Intermediate Metabolizers (IMs): These people have reduced enzyme activity. They metabolize drugs slower than normal metabolizers but faster than poor metabolizers.
  3. Extensive Metabolizers (EMs): This is the "standard" or "expected" rate of metabolization. Drugs are metabolized at a regular rate, leading to expected drug efficacy and side effects.
  4. Ultrarapid Metabolizers (UMs): These individuals have increased enzyme activity. They break down certain drugs very quickly, which can decrease the effectiveness of the drug because it's cleared from their system too rapidly.

In conclusion, understanding one's haplotype and consequent metabolizer status can be crucial for personalized medicine. It can provide guidance on drug selection and dosing to optimize therapeutic outcomes and minimize adverse reactions.

Dr. Wallerstorfer

Pharmacogenetics

The CYP2C19*32 haplotype is linked to the CYP2C19 gene, a key component in the body's drug-processing system. This gene provides the blueprint for an enzyme pivotal in breaking down a range of medicines. The presence of the CYP2C19*32 haplotype can influence the efficiency of this enzyme. Based on its activity score, individuals with this haplotype might be classified as poor, intermediate, normal, or ultrarapid metabolizers. This classification is vital as it dictates how rapidly one processes certain medications, potentially impacting the drug's efficacy and risk of side effects. Recognizing the presence of CYP2C19*32 in an individual can guide healthcare professionals in tailoring medication doses to achieve optimal therapeutic outcomes.

there are 21 Drugs associated with 21 Variants that are located on CYP2C19

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