Overview

CYP2B6*1 is a specific haplotype found on the cytochrome P450 family 2 subfamily B member 6 gene.  This haplotype is intricately connected to 29 specific variants. It plays a significant role in how individuals metabolize certain drugs, especially cyclophosphamide, efavirenz, mirtazapine, nicotine, isoniazid, pyrazinamide, rifampin, artemether. CYP2B6*1 has a Haplotype Performance of 100%. The combined haplotype performances of two haplotypes and individual posseses on cytochrome P450 family 2 subfamily B member 6 determines the overall gene performance. The gene performance indicates the metabolism rate, classifying individuals as either poor, intermediate, extensive, or ultrarapid metabolizers. This has a direct influence on how they process certain drugs.

Role of the Gene that carries the Haplotype CYP2B6*1

The gene cytochrome P450 family 2 subfamily B member 6, plays a crucial role in the way our body processes fat by breaking it down and managing its levels. This occurs mostly in the liver, an essential organ for maintaining healthy body functions. The gene can lead to a change in the protein structure, potentially causing inefficient breakdown of fat. This may contribute to an increased risk of developing liver-related health issues such as fatty liver disease. While genetics play a part, maintaining a healthy lifestyle can help minimize these risks.

CYP2B6*1

% Haplotype Performance:

100%

This is the standard or typical haplotype performance. The haplotype performance is at a "normal" level.

The haplotype performances of two haplotypes an individual possess on cytochrome P450 family 2 subfamily B member 6 determines their overall gene performance.

100% Haplotype Performance

The haplotype performance of a haplotype, when considering drug metabolization, provides a quantifiable measure of how effectively a person's genetics might influence their ability to metabolize or break down specific drugs. The combined effect of the two haplotypes you possess (i.e., the two sets of variants) will determine your overall gene performance related to drug metabolism.

Set of variants that define CYP2B6*1

Haplotypes are linked to multiple variants, and each variant in the haplotype has a specific allele.

there are 29 Variants linked to CYP2B6*1 in the databse:

CYP2B6*1

Variant
Allele
Summary

rs2279343

A

rs2279343 is a genetic variant on gene CYP2B6.

rs3211369

A

rs3211369 is a genetic variant on gene CYP2B6.

rs3211371

C

rs3211371 is a genetic variant on gene CYP2B6.

rs3745274

G

rs3745274 is a genetic variant on gene CYP2B6.

rs3826711

C

rs3826711 is a genetic variant on gene CYP2B6.

rs8192709

C

rs8192709 is a genetic variant on gene CYP2B6.

rs12721655

A

rs12721655 is a genetic variant on gene CYP2B6.

rs28399499

T

rs28399499 is a genetic variant on gene CYP2B6.

rs33926104

C

rs33926104 is a genetic variant on gene CYP2B6.

rs33973337

A

rs33973337 is a genetic variant on gene CYP2B6.

rs33980385

A

rs33980385 is a genetic variant on gene CYP2B6.

rs34097093

C

rs34097093 is a genetic variant on gene CYP2B6.

rs34223104

T

rs34223104 is a genetic variant.

rs34284776

G

rs34284776 is a genetic variant on gene CYP2B6.

rs34826503

C

rs34826503 is a genetic variant on gene CYP2B6.

rs34883432

A

rs34883432 is a genetic variant on gene CYP2B6.

rs35010098

C

rs35010098 is a genetic variant on gene CYP2B6.

rs35303484

A

rs35303484 is a genetic variant on gene CYP2B6.

rs35773040

G

rs35773040 is a genetic variant on gene CYP2B6.

rs35979566

T

rs35979566 is a genetic variant on gene CYP2B6.

rs36056539

C

rs36056539 is a genetic variant on gene CYP2B6.

rs36060847

G

rs36060847 is a genetic variant on gene CYP2B6.

rs36079186

T

rs36079186 is a genetic variant on gene CYP2B6.

rs45482602

C

rs45482602 is a genetic variant on gene CYP2B6.

rs58871670

G

rs58871670 is a genetic variant on gene CYP2B6.

rs139801276

T

rs139801276 is a genetic variant on gene CYP2B6.

rs186335453

G

rs186335453 is a genetic variant on gene CYP2B6.

rs281864907

T

rs281864907 is a genetic variant on gene CYP2B6.

rs373489637

T

rs373489637 is a genetic variant on gene CYP2B6.

CYP2B6*1

Name

rs2279343

Allele

A

Summary

rs2279343 is a genetic variant on gene CYP2B6.

Name

rs3211369

Allele

A

Summary

rs3211369 is a genetic variant on gene CYP2B6.

Name

rs3211371

Allele

C

Summary

rs3211371 is a genetic variant on gene CYP2B6.

Name

rs3745274

Allele

G

Summary

rs3745274 is a genetic variant on gene CYP2B6.

Name

rs3826711

Allele

C

Summary

rs3826711 is a genetic variant on gene CYP2B6.

Name

rs8192709

Allele

C

Summary

rs8192709 is a genetic variant on gene CYP2B6.

Name

rs12721655

Allele

A

Summary

rs12721655 is a genetic variant on gene CYP2B6.

Name

rs28399499

Allele

T

Summary

rs28399499 is a genetic variant on gene CYP2B6.

Name

rs33926104

Allele

C

Summary

rs33926104 is a genetic variant on gene CYP2B6.

Name

rs33973337

Allele

A

Summary

rs33973337 is a genetic variant on gene CYP2B6.

Name

rs33980385

Allele

A

Summary

rs33980385 is a genetic variant on gene CYP2B6.

Name

rs34097093

Allele

C

Summary

rs34097093 is a genetic variant on gene CYP2B6.

Name

rs34223104

Allele

T

Summary

rs34223104 is a genetic variant.

Name

rs34284776

Allele

G

Summary

rs34284776 is a genetic variant on gene CYP2B6.

Name

rs34826503

Allele

C

Summary

rs34826503 is a genetic variant on gene CYP2B6.

Name

rs34883432

Allele

A

Summary

rs34883432 is a genetic variant on gene CYP2B6.

Name

rs35010098

Allele

C

Summary

rs35010098 is a genetic variant on gene CYP2B6.

Name

rs35303484

Allele

A

Summary

rs35303484 is a genetic variant on gene CYP2B6.

Name

rs35773040

Allele

G

Summary

rs35773040 is a genetic variant on gene CYP2B6.

Name

rs35979566

Allele

T

Summary

rs35979566 is a genetic variant on gene CYP2B6.

Name

rs36056539

Allele

C

Summary

rs36056539 is a genetic variant on gene CYP2B6.

Name

rs36060847

Allele

G

Summary

rs36060847 is a genetic variant on gene CYP2B6.

Name

rs36079186

Allele

T

Summary

rs36079186 is a genetic variant on gene CYP2B6.

Name

rs45482602

Allele

C

Summary

rs45482602 is a genetic variant on gene CYP2B6.

Name

rs58871670

Allele

G

Summary

rs58871670 is a genetic variant on gene CYP2B6.

Name

rs139801276

Allele

T

Summary

rs139801276 is a genetic variant on gene CYP2B6.

Name

rs186335453

Allele

G

Summary

rs186335453 is a genetic variant on gene CYP2B6.

Name

rs281864907

Allele

T

Summary

rs281864907 is a genetic variant on gene CYP2B6.

Name

rs373489637

Allele

T

Summary

rs373489637 is a genetic variant on gene CYP2B6.

Did you know that haplotypes play a major role in pharmacogenetics?

Certain haplotypes in combination can influence how a person's body metabolizes drugs. This is because these haplotypes can affect the function of enzymes responsible for drug metabolism. A change or variation in the DNA sequence of a gene that codes for a drug-metabolizing enzyme can increase or decrease the activity of that enzyme.

Based on the activity of these enzymes (influenced by haplotypes), individuals can be classified into different metabolizer categories:

  1. Poor Metabolizers (PMs): These individuals have little or no enzyme activity due to certain genetic variations. As a result, they might not metabolize certain drugs efficiently, leading to a higher risk of side effects because the drug remains in their system for a longer time.
  2. Intermediate Metabolizers (IMs): These people have reduced enzyme activity. They metabolize drugs slower than normal metabolizers but faster than poor metabolizers.
  3. Extensive Metabolizers (EMs): This is the "standard" or "expected" rate of metabolization. Drugs are metabolized at a regular rate, leading to expected drug efficacy and side effects.
  4. Ultrarapid Metabolizers (UMs): These individuals have increased enzyme activity. They break down certain drugs very quickly, which can decrease the effectiveness of the drug because it's cleared from their system too rapidly.

In conclusion, understanding one's haplotype and consequent metabolizer status can be crucial for personalized medicine. It can provide guidance on drug selection and dosing to optimize therapeutic outcomes and minimize adverse reactions.

Dr. Wallerstorfer

Pharmacogenetics

The CYP2B6*1 haplotype is linked to the CYP2B6 gene, a key component in the body's drug-processing system. This gene provides the blueprint for an enzyme pivotal in breaking down a range of medicines. The presence of the CYP2B6*1 haplotype can influence the efficiency of this enzyme. Based on its activity score, individuals with this haplotype might be classified as poor, intermediate, normal, or ultrarapid metabolizers. This classification is vital as it dictates how rapidly one processes certain medications, potentially impacting the drug's efficacy and risk of side effects. Recognizing the presence of CYP2B6*1 in an individual can guide healthcare professionals in tailoring medication doses to achieve optimal therapeutic outcomes.

there are 10 Drugs associated with 10 Variants that are located on CYP2B6

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