Genes
COMT
This gene is related to these conditions:
Effect of Variations on the COMT
Variants are common variations in genes that can significantly impact the health and traits of an individual. This section shows all variants that are located on COMT, as well as their associated conditions, traits and drugs.
Did you know that gene anomalies are relatively common?
On average, each person has approximately 100 to 400 genes with variations or mutations (with different genes being affected in different individuals). However, in most cases, the matching gene on the other chromosome in the pair is normal, which helps prevent potential negative effects. In the general population, the likelihood of an individual inheriting two copies of the same abnormal gene—and thus developing a genetic disorder—is very low. However, this risk increases significantly for children of parents who are closely related by blood.
Dr. Wallerstorfer
Conditions caused and influenced by COMT
Genetic abnormalities can affect the chance of developing a condition by raising or lowering the risk. They can change how a gene works, leading to faulty or missing proteins. However, even with a higher genetic risk, a condition may not develop because factors like environment and lifestyle also have an impact.
Variants located on COMT
The genetic code of a gene is virtually identical between differen people. Only a few individual letters differ from one person to the next.
Did you know genetic variations may affect drugs?
Genetic differences can affect how our body reacts to drugs. Some genes can make a drug work better or worse, and others can change how safe it is or how much of it you need.
Dr. Wallerstorfer
Pharmacogenetics
Genetic differences can affect how our bodies respond to medications. Some people’s genes can make a drug work better or worse, change how safe it is, or influence how much of the drug they need. These genetic changes can affect how the body processes medicine, like how quickly it is broken down or how it interacts with cells. For example, a genetic difference might cause a person’s body to break down a drug too fast, making it less effective, or too slowly, increasing the risk of side effects. This is why people can have different reactions to the same medication.
rs4633
Drug
Genotype
Level of evidence
Impacts
Summary
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have decreased Drug Effect to RISPERIDONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Drug Effect to RISPERIDONE.
more info
Legend:
Increased
Decreased
No known effect
rs4680
Drug
Genotype
Level of evidence
Impacts
Summary
BUPRENORPHINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Dosage to BUPRENORPHINE.
more info
BUPRENORPHINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Drug Effect to BUPRENORPHINE.
more info
BUPRENORPHINE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
CLOZAPINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to CLOZAPINE.
more info
CLOZAPINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Drug Effect to CLOZAPINE.
more info
CLOZAPINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to CLOZAPINE.
more info
ENTACAPONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to ENTACAPONE.
more info
ENTACAPONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Drug Effect to ENTACAPONE.
more info
ENTACAPONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to ENTACAPONE.
more info
FENTANYL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to FENTANYL.
more info
FENTANYL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Drug Effect to FENTANYL.
more info
FENTANYL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to FENTANYL.
more info
HALOPERIDOL
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
HALOPERIDOL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Side Effects to HALOPERIDOL.
more info
HALOPERIDOL
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
METHYLPHENIDATE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
METHYLPHENIDATE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
METHYLPHENIDATE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
MODAFINIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to MODAFINIL.
more info
MODAFINIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Drug Effect to MODAFINIL.
more info
MODAFINIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to MODAFINIL.
more info
NICOTINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Drug Effect to NICOTINE.
more info
NICOTINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Drug Effect to NICOTINE.
more info
NICOTINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have decreased Drug Effect to NICOTINE.
more info
OXYCODONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Side Effects to OXYCODONE.
more info
OXYCODONE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
OXYCODONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Side Effects to OXYCODONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to RISPERIDONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Drug Effect to RISPERIDONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to RISPERIDONE.
more info
Legend:
Increased
Decreased
No known effect
rs4818
Drug
Genotype
Level of evidence
Impacts
Summary
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect to RISPERIDONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/G have increased Drug Effect to RISPERIDONE.
more info
RISPERIDONE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
rs4633
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have decreased Drug Effect to RISPERIDONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Drug Effect to RISPERIDONE.
More info
Legend:
Increased
Decreased
No known effect
rs4680
Drug
BUPRENORPHINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Dosage to BUPRENORPHINE.
More info
Drug
BUPRENORPHINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Drug Effect to BUPRENORPHINE.
More info
Drug
BUPRENORPHINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
CLOZAPINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to CLOZAPINE.
More info
Drug
CLOZAPINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Drug Effect to CLOZAPINE.
More info
Drug
CLOZAPINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to CLOZAPINE.
More info
Drug
ENTACAPONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to ENTACAPONE.
More info
Drug
ENTACAPONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Drug Effect to ENTACAPONE.
More info
Drug
ENTACAPONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to ENTACAPONE.
More info
Drug
FENTANYL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to FENTANYL.
More info
Drug
FENTANYL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Drug Effect to FENTANYL.
More info
Drug
FENTANYL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to FENTANYL.
More info
Drug
HALOPERIDOL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
HALOPERIDOL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Side Effects to HALOPERIDOL.
More info
Drug
HALOPERIDOL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
METHYLPHENIDATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
METHYLPHENIDATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
METHYLPHENIDATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
MODAFINIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to MODAFINIL.
More info
Drug
MODAFINIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Drug Effect to MODAFINIL.
More info
Drug
MODAFINIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to MODAFINIL.
More info
Drug
NICOTINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Drug Effect to NICOTINE.
More info
Drug
NICOTINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Drug Effect to NICOTINE.
More info
Drug
NICOTINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have decreased Drug Effect to NICOTINE.
More info
Drug
OXYCODONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Side Effects to OXYCODONE.
More info
Drug
OXYCODONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
OXYCODONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Side Effects to OXYCODONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to RISPERIDONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Drug Effect to RISPERIDONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to RISPERIDONE.
More info
Legend:
Increased
Decreased
No known effect
rs4818
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect to RISPERIDONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/G have increased Drug Effect to RISPERIDONE.
More info
Drug
RISPERIDONE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Legend:
Increased
Decreased
No known effect