Overview

rs951439 is a genetic variant.

This variant is located on chromosome 1. The variations at position 163063901 are the genetic letters C/C, T/T, C/T

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs951439 there are 3 currently known genotypes : C/C, T/T or C/T

Short Overview

Variant Location

rs951439 is located on gene in chromsome 1. Use the genome browser to explore the location of rs951439 and its genetic neighbourhood.

Conditions & Traits

rs951439 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs951439.

Pathogenicity

rs951439 affects the following conditions:

There are currently 0 conditions associated with rs951439.

Pharmacogenetics

rs951439 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs951439

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs951439 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs951439. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have increased Drug Effect to OLANZAPINE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Drug Effect to OLANZAPINE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Drug Effect to OLANZAPINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have increased Drug Effect to PERPHENAZINE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Drug Effect to PERPHENAZINE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Drug Effect to PERPHENAZINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have decreased Drug Effect to RISPERIDONE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have decreased Drug Effect to RISPERIDONE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Drug Effect to RISPERIDONE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have increased Drug Effect to OLANZAPINE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have increased Drug Effect to OLANZAPINE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Drug Effect to OLANZAPINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have increased Drug Effect to PERPHENAZINE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have increased Drug Effect to PERPHENAZINE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Drug Effect to PERPHENAZINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have decreased Drug Effect to RISPERIDONE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have decreased Drug Effect to RISPERIDONE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Drug Effect to RISPERIDONE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs951439

All drugs that are linked to rs951439 are listed here.

Studies and Sources

All of the resources below examine variant rs951439

Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios (December 2005)

M. Daniele  Fallin, Virginia K.  Lasseter, Dimitrios  Avramopoulos, Kristin K.  Nicodemus, Paula S.  Wolyniec, John A.  McGrath, Gary  Steel, Gerald  Nestadt, Kung-Yee  Liang, Richard L.  Huganir, David  Valle, Ann E.  Pulver

PMC: 1285177
Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia (1/3/08)

Daniel B. Campbell, Philip J. Ebert, Tara Skelly, T. Scott Stroup, Jeffrey Lieberman, Pat Levitt, Patrick F. Sullivan

PMC: 2194758
ASSOCIATION OF RGS2 AND RGS5 VARIANTS WITH SCHIZOPHRENIA SYMPTOM SEVERITY (6/16/08)

Daniel B. Campbell, Leslie A. Lange, Tara Skelly, Jeffrey Lieberman, Pat Levitt, Patrick F. Sullivan

PMC: 2486404
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