Overview
rs11540652 is a genetic variant on gene TP53 associated with Bone osteosarcoma and Breast carcinoma.
This variant is located on chromosome 17. The variations at position 7674220 are the genetic letters A/A, C/C, G/G, T/T, A/C, C/G, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs11540652 there are 7 currently known genotypes : A/A, C/C, G/G, T/T, A/C, C/G or C/T
Short Overview
Variant Location
rs11540652 is located on gene TP53 in chromsome 17. Use the genome browser to explore the location of rs11540652 and its genetic neighbourhood.
Conditions & Traits
rs11540652 affects the following conditions and traits:
Pathogenicity
rs11540652 affects the following conditions:
Pharmacogenetics
We do not have any data that links rs11540652 to any drugs.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene TP53. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs11540652
The different genotypes of variant rs11540652 can affect the likelyhood of developing certain traits or conditions. Current research shows that 18 conditions and 0 traits are associated with rs11540652. The following table shows the relationship between genotypes and conditions and traits.
Classification of Variants
Variants can be classified either based on scientific studies or clinical tests. Scientific studies classifications aim to uncover the function of genetic variants and their role in conditions, traits, and evolution. Variants are categorized according to their functional effect, such as loss-of-function (reduced gene activity), gain-of-function (increased gene activity), neutral (no significant impact) or evolutionary conservation. This classification uses experimental data, population studies, and computational analyses to understand the long-term effects of variants. Clinical testing classifications, however, focus on the immediate health impact on the human body, distinguishing five categories from disease causing (harmful) to no effect (not harmful). This classification relies on a mix of family history, lab tests, and computer predictions, aiming to assist doctors in making medical decisions.
Conditions
18Genotype
A
A
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters A/A is considered disease causing. Carriers of this genetic result are typically affected by the disease.
Genotype
C
C
Level of evidence
Sources
No effect
Unisex
3 Sources
Participants: 0
The genotype with the letters C/C is thought to have no effect on your disease risk. Carriers of this genetic result are usually not at risk of developing the disease.
Genotype
A
C
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters A/C is considered disease causing. Carriers of this genetic result are typically affected by the disease.
Genotype
G
G
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters G/G is considered disease causing. Carriers of this genetic result are typically affected by the disease.
Genotype
C
G
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters C/G is considered disease causing. Carriers of this genetic result are typically affected by the disease.
Genotype
T
T
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters T/T is considered disease causing. Carriers of this genetic result are typically affected by the disease.
Genotype
C
T
Level of evidence
Sources
Disease causing
Unisex
1 Sources
Participants: 0
The genotype with the letters C/T is considered disease causing. Carriers of this genetic result are typically affected by the disease.