Overview

rs760370 is a genetic variant.

This variant is located on chromosome 6. The variations at position 44233216 are the genetic letters A/A, G/G, A/G

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs760370 there are 3 currently known genotypes : A/A, G/G or A/G

Short Overview

Variant Location

rs760370 is located on gene in chromsome 6. Use the genome browser to explore the location of rs760370 and its genetic neighbourhood.

Conditions & Traits

rs760370 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs760370.

Pathogenicity

rs760370 affects the following conditions:

There are currently 0 conditions associated with rs760370.

Pharmacogenetics

rs760370 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs760370

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs760370 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs760370. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have decreased Drug Effect to RIBAVIRIN.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have decreased Drug Effect to RIBAVIRIN.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to RIBAVIRIN.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have decreased Drug Effect to TIPIRACIL HYDROCHLORIDE.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have increased Drug Effect to TIPIRACIL HYDROCHLORIDE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to TIPIRACIL HYDROCHLORIDE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have decreased Drug Effect to TRIFLURIDINE.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have increased Drug Effect to TRIFLURIDINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to TRIFLURIDINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have decreased Drug Effect to RIBAVIRIN.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have decreased Drug Effect to RIBAVIRIN.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to RIBAVIRIN.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have decreased Drug Effect to TIPIRACIL HYDROCHLORIDE.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have increased Drug Effect to TIPIRACIL HYDROCHLORIDE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to TIPIRACIL HYDROCHLORIDE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have decreased Drug Effect to TRIFLURIDINE.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have increased Drug Effect to TRIFLURIDINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to TRIFLURIDINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs760370

All drugs that are linked to rs760370 are listed here.

Studies and Sources

All of the resources below examine variant rs760370

Polymorphisms of ADME-related genes and their implications for drug safety and efficacy in Amazonian Amerindians (5/10/19)

Juliana Carla Gomes Rodrigues, Marianne Rodrigues Fernandes, João Farias Guerreiro, Artur Luiz da Costa da Silva, Ândrea Ribeiro-dos-Santos, Sidney Santos, Ney Pereira Carneiro dos Santos

PMC: 6510895
Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease (10/13/20)

Concetta Cafiero, Agnese Re, Alessandra Micera, Raffaele Palmirotta, Delio Monaco, Francesca Romano, Claudia Fabrizio, Raffaele Di Francia, Andrea Cacciamani, Pier Luigi Surico, Gerardo D’Amato, Salvatore Pisconti

PMC: 7568633
Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population (5/29/21)

Natasha Monte, Karla B. C. C. Pantoja, Juliana C. G. Rodrigues, Darlen C. de Carvalho, Tereza C. B. Azevedo, Esdras E. B. Pereira, Paulo P. de Assumpção, Sidney E. B. dos Santos, Marianne R. Fernandes, Ney P. C. dos Santos

PMC: 8372092
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