Overview

rs746647 is a genetic variant.

This variant is located on chromosome 6. The variations at position 31146405 are the genetic letters A/A, G/G, A/G

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs746647 there are 3 currently known genotypes : A/A, G/G or A/G

Short Overview

Variant Location

rs746647 is located on gene in chromsome 6. Use the genome browser to explore the location of rs746647 and its genetic neighbourhood.

Conditions & Traits

rs746647 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs746647.

Pathogenicity

rs746647 affects the following conditions:

There are currently 0 conditions associated with rs746647.

Pharmacogenetics

rs746647 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs746647

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs746647 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs746647. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have increased Side Effects to NEVIRAPINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Side Effects to NEVIRAPINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have increased Side Effects to NEVIRAPINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Side Effects to NEVIRAPINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs746647

All drugs that are linked to rs746647 are listed here.

Studies and Sources

All of the resources below examine variant rs746647

Paradoxical psoriasis induced by TNF‐α blockade shows immunological features typical of the early phase of psoriasis development (10/29/19)

Luca Fania, Martina Morelli, Claudia Scarponi, Laura Mercurio, Fernanda Scopelliti, Caterina Cattani, Giovanni Luca Scaglione, Tiziano Tonanzi, Maria Antonietta Pilla, Gianluca Pagnanelli, Cinzia Mazzanti, Giampiero Girolomoni, Andrea Cavani, Stefania Madonna, Cristina Albanesi

PMC: 6966707
Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions (1/13/21)

Hang Tong, Nga V T Phan, Thanh T Nguyen, Dinh V Nguyen, Nam S Vo, Ly Le

PMC: 7812041
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