Overview
rs735482 is a genetic variant on gene ERCC1.
This variant is located on chromosome 19. The variations at position 45408744 are the genetic letters A/A, C/C, A/C
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs735482 there are 3 currently known genotypes : A/A, C/C or A/C
Short Overview
Variant Location
rs735482 is located on gene ERCC1 in chromsome 19. Use the genome browser to explore the location of rs735482 and its genetic neighbourhood.
Conditions & Traits
rs735482 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs735482.
Pathogenicity
rs735482 affects the following conditions:
There are currently 0 conditions associated with rs735482.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene ERCC1. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs735482
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs735482 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs735482. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to THALIDOMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/C have increased Drug Effect to THALIDOMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to THALIDOMIDE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to THALIDOMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/C have increased Drug Effect to THALIDOMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to THALIDOMIDE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs735482
All drugs that are linked to rs735482 are listed here.
Studies and Sources
All of the resources below examine variant rs735482
Junjun Wang, Qingyun Liu, Shuai Yuan, Weijia Xie, Yuan Liu, Ying Xiang, Na Wu, Long Wu, Xiangyu Ma, Tongjian Cai, Yao Zhang, Zhifu Sun, Yafei Li
Qianye Zhang, Xiao Zheng, Xiaoxia Li, Deyu Sun, Ping Xue, Guopei Zhang, Mingyang Xiao, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu
Tao Yu, Ping Xue, Su Cui, Liang Zhang, Guopei Zhang, Mingyang Xiao, Xiao Zheng, Qianye Zhang, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu