Overview
rs4986893 is a genetic variant on gene CYP2C19.
This variant is located on chromosome 10. The variations at position 94780653 are the genetic letters A/A, G/G, A/G
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs4986893 there are 3 currently known genotypes : A/A, G/G or A/G
Short Overview
Variant Location
rs4986893 is located on gene CYP2C19 in chromsome 10. Use the genome browser to explore the location of rs4986893 and its genetic neighbourhood.
Conditions & Traits
rs4986893 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs4986893.
Pathogenicity
rs4986893 affects the following conditions:
There are currently 0 conditions associated with rs4986893.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene CYP2C19. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs4986893
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs4986893 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs4986893. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Side Effects to ISONIAZID.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Side Effects to ISONIAZID.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Side Effects to ISONIAZID.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Side Effects to PYRAZINAMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Side Effects to PYRAZINAMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Side Effects to PYRAZINAMIDE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Side Effects to RIFAMPIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Side Effects to RIFAMPIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Side Effects to RIFAMPIN.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Side Effects to ISONIAZID.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Side Effects to ISONIAZID.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Side Effects to ISONIAZID.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Side Effects to PYRAZINAMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Side Effects to PYRAZINAMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Side Effects to PYRAZINAMIDE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Side Effects to RIFAMPIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Side Effects to RIFAMPIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Side Effects to RIFAMPIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs4986893
All drugs that are linked to rs4986893 are listed here.
Studies and Sources
All of the resources below examine variant rs4986893
Yunfeng Ruan, Jie Jiang, Liang Guo, Yan Li, Hailiang Huang, Lu Shen, Mengqi Luan, Mo Li, Huihui Du, Cheng Ma, Lin He, Xiaoqing Zhang, Shengying Qin
Sung-Hsin Kuo, Shi-Yi Yang, San-Lin You, Huang-Chun Lien, Ching-Hung Lin, Po-Han Lin, Chiun-Sheng Huang
Sumiko Ohnami, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Fukumi Kamada, Junko Saito, Akane Naruoka, Masakuni Serizawa, Yoko Masuda, Shumpei Ohnami, Masatoshi Kusuhara, Ken Yamaguchi