Overview
rs3212986 is a genetic variant on gene ERCC1.
This variant is located on chromosome 19. The variations at position 45409478 are the genetic letters A/A, C/C, A/C, A/G
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs3212986 there are 4 currently known genotypes : A/A, C/C, A/C or A/G
Short Overview
Variant Location
rs3212986 is located on gene ERCC1 in chromsome 19. Use the genome browser to explore the location of rs3212986 and its genetic neighbourhood.
Conditions & Traits
rs3212986 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs3212986.
Pathogenicity
rs3212986 affects the following conditions:
There are currently 0 conditions associated with rs3212986.
Pharmacogenetics
rs3212986 affects the following drugs:
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene ERCC1. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs3212986
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs3212986 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs3212986. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect and increased Side Effects to CISPLATIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/C have increased Side Effects to CISPLATIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have decreased Drug Effect to CISPLATIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect and increased Side Effects to CISPLATIN.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Side Effects to CYCLOPHOSPHAMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Side Effects to DOCETAXEL.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect and increased Side Effects to CISPLATIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/C have increased Side Effects to CISPLATIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have decreased Drug Effect to CISPLATIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect and increased Side Effects to CISPLATIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Side Effects to CYCLOPHOSPHAMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Side Effects to DOCETAXEL.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs3212986
All drugs that are linked to rs3212986 are listed here.
Studies and Sources
All of the resources below examine variant rs3212986
Fatemeh Hajibabaie, Navid Abedpoor, Nazanin Assareh, Mohammad Amin Tabatabaiefar, Laleh Shariati, Ali Zarrabi
Claudia Weilbeer, David Jay, James C. Donnelly, Francesco Gentile, Feridoun Karimi-Busheri, Xiaoyan Yang, Rajam S. Mani, Yaping Yu, Ahmed H. Elmenoufy, Khaled H. Barakat, Jack A. Tuszynski, Michael Weinfeld, Frederick G. West
Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid, Ali Raza