Overview
rs25487 is a genetic variant on gene XRCC1.
This variant is located on chromosome 19. The variations at position 43551574 are the genetic letters C/C, T/T, G/T, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs25487 there are 4 currently known genotypes : C/C, T/T, G/T or C/T
Short Overview
Variant Location
rs25487 is located on gene XRCC1 in chromsome 19. Use the genome browser to explore the location of rs25487 and its genetic neighbourhood.
Conditions & Traits
rs25487 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs25487.
Pathogenicity
rs25487 affects the following conditions:
There are currently 0 conditions associated with rs25487.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene XRCC1. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs25487
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs25487 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs25487. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have decreased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to FLUOROURACIL.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have decreased Drug Effect and increased Side Effects to FLUOROURACIL.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Drug Effect and increased Side Effects to FLUOROURACIL.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have decreased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Drug Effect and increased Side Effects to CYCLOPHOSPHAMIDE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to FLUOROURACIL.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have decreased Drug Effect and increased Side Effects to FLUOROURACIL.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Drug Effect and increased Side Effects to FLUOROURACIL.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs25487
All drugs that are linked to rs25487 are listed here.
Studies and Sources
All of the resources below examine variant rs25487
Noel E Donlon, Maria Davern, Fiona O’Connell, Andrew Sheppard, Aisling Heeran, Anshul Bhardwaj, Christine Butler, Ravi Narayanasamy, Claire Donohoe, James J Phelan, Niamh Lynam-Lennon, Margaret R Dunne, Stephen Maher, Jacintha O’Sullivan, John V Reynolds, Joanne Lysaght
Jelena Spasic, Milena Cavic, Nemanja Stanic, Bojan Zaric, Tomi Kovacevic, Davorin Radosavljevic, Ljudmila Nagorni-Obradovic
Sumitaka Kobayashi, Fumihiro Sata, Reiko Kishi