Overview

rs20455 is a genetic variant on gene KIF6.

This variant is located on chromosome 6. The variations at position 39357302 are the genetic letters A/A, G/G, A/G

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs20455 there are 3 currently known genotypes : A/A, G/G or A/G

Short Overview

Variant Location

rs20455 is located on gene KIF6 in chromsome 6. Use the genome browser to explore the location of rs20455 and its genetic neighbourhood.

Conditions & Traits

rs20455 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs20455.

Pathogenicity

rs20455 affects the following conditions:

There are currently 0 conditions associated with rs20455.

Pharmacogenetics

rs20455 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene KIF6. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs20455

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs20455 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs20455. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

No summary available.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have decreased Drug Effect to SIMVASTATIN.

more info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

No summary available.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have decreased Drug Effect to SIMVASTATIN.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs20455

All drugs that are linked to rs20455 are listed here.

Studies and Sources

All of the resources below examine variant rs20455

Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population (12/24/17)

Sabrina Angelini, Martina Rosticci, Gianmichele Massimo, Muriel Musti, Gloria Ravegnini, Nicola Consolini, Giulia Sammarini, Sergio D’Addato, Elisabetta Rizzoli, Dauren Botbayev, Claudio Borghi, Giorgio Cantelli-Forti, Arrigo F. Cicero, Patrizia Hrelia

PMC: 5795999
The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women’s Health Initiative observational study (11/18/17)

Cathryn H. Bock, Allison M. Jay, Gregory Dyson, Jennifer L. Beebe-Dimmer, Michele L. Cote, Lifang Hou, Barbara V. Howard, Pinkal Desai, Kristen Purrington, Ross Prentice, Michael S. Simon

PMC: 5809196
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