Overview

rs1799732 is a genetic variant.

This variant is located on chromosome 11. The variations at position 113475530 are the genetic letters -/-, G/-, G/G

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1799732 there are 3 currently known genotypes : -/-, G/- or G/G

Short Overview

Variant Location

rs1799732 is located on gene in chromsome 11. Use the genome browser to explore the location of rs1799732 and its genetic neighbourhood.

Conditions & Traits

rs1799732 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs1799732.

Pathogenicity

rs1799732 affects the following conditions:

There are currently 0 conditions associated with rs1799732.

Pharmacogenetics

rs1799732 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs1799732

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs1799732 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1799732. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
--

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype -/- have decreased Drug Effect to ARIPIPRAZOLE.

more info

G-

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/- have decreased Drug Effect to ARIPIPRAZOLE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to ARIPIPRAZOLE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
--

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype -/- have decreased Drug Effect to CHLORPROMAZINE.

more info

G-

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/- have decreased Drug Effect to CHLORPROMAZINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to CHLORPROMAZINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
--

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype -/- have decreased Drug Effect to CLOZAPINE.

more info

G-

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/- have decreased Drug Effect to CLOZAPINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have increased Drug Effect to CLOZAPINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
--
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype -/- have decreased Drug Effect to ARIPIPRAZOLE.

Level of evidence

More info

Genotype
G-
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/- have decreased Drug Effect to ARIPIPRAZOLE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to ARIPIPRAZOLE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
--
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype -/- have decreased Drug Effect to CHLORPROMAZINE.

Level of evidence

More info

Genotype
G-
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/- have decreased Drug Effect to CHLORPROMAZINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to CHLORPROMAZINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
--
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype -/- have decreased Drug Effect to CLOZAPINE.

Level of evidence

More info

Genotype
G-
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/- have decreased Drug Effect to CLOZAPINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have increased Drug Effect to CLOZAPINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs1799732

All drugs that are linked to rs1799732 are listed here.

Studies and Sources

All of the resources below examine variant rs1799732

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. (1/28/08)

Ying Zhang, Alessandro Bertolino, Leonardo Fazio, Giuseppe Blasi, Antonio Rampino, Raffaella Romano, Mei-Ling T Lee, Tao Xiao, Audrey Papp, Danxin Wang, Wolfgang Sadée

PubMed: 18077373
Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies. (2/3/12)

Dingyan Chen, Fang Liu, Qinggang Shang, Xiaoqin Song, Xiaoping Miao, Zengzhen Wang

PubMed: 21714067
Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. (1/21/13)

Caroline Davis, Robert D Levitan, Zeynep Yilmaz, Allan S Kaplan, Jacqueline C Carter, James L Kennedy

PubMed: 22579533
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