Overview

rs1561876 is a genetic variant on gene STIM1.

This variant is located on chromosome 11. The variations at position 4092165 are the genetic letters A/A, G/G, C/G, G/T, A/G

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1561876 there are 5 currently known genotypes : A/A, G/G, C/G, G/T or A/G

Short Overview

Variant Location

rs1561876 is located on gene STIM1 in chromsome 11. Use the genome browser to explore the location of rs1561876 and its genetic neighbourhood.

Conditions & Traits

rs1561876 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs1561876.

Pathogenicity

rs1561876 affects the following conditions:

There are currently 0 conditions associated with rs1561876.

Pharmacogenetics

rs1561876 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene STIM1. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs1561876

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs1561876 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1561876. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have increased Drug Effect to CLADRIBINE.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have increased Drug Effect to CLADRIBINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have decreased Drug Effect to CLADRIBINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
AA

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/A have increased Drug Effect to CYTARABINE.

more info

AG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype A/G have increased Drug Effect to CYTARABINE.

more info

GG

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype G/G have decreased Drug Effect to CYTARABINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have increased Drug Effect to CLADRIBINE.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have increased Drug Effect to CLADRIBINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have decreased Drug Effect to CLADRIBINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
AA
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/A have increased Drug Effect to CYTARABINE.

Level of evidence

More info

Genotype
AG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype A/G have increased Drug Effect to CYTARABINE.

Level of evidence

More info

Genotype
GG
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype G/G have decreased Drug Effect to CYTARABINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs1561876

All drugs that are linked to rs1561876 are listed here.

Studies and Sources

All of the resources below examine variant rs1561876

Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients

James Cheng-Chung Wei, Kuo-Sheng Hung, Yu-Wen Hsu, Ruey-Hong Wong, Chun-Huang Huang, Ming-Shiou Jan, Shyh-Jong Wu, Yung-Shun Juan, Wei-Chiao Chang

PMC: 3522685
RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients (11/25/13)

Xueyuan Cao, Amit K Mitra, Stanley Pounds, Kristine R Crews, Varsha Gandhi, William Plunkett, M Eileen Dolan, Christine Hartford, Susana Raimondi, Dario Campana, James Downing, Jeffrey E Rubnitz, Raul C Ribeiro, Jatinder K Lamba

PMC: 3860742
Potentially Functional SNPs (pfSNPs) as Novel Genomic Predictors of 5-FU Response in Metastatic Colorectal Cancer Patients

Jingbo Wang, Xu Wang, Mingjue Zhao, Su Pin Choo, Sin Jen Ong, Simon Y. K. Ong, Samuel S. Chong, Yik Ying Teo, Caroline G. L. Lee

PMC: 4221105
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