Overview
rs12659 is a genetic variant on gene SLC19A1.
This variant is located on chromosome 21. The variations at position 45531642 are the genetic letters A/A, G/G, A/G
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs12659 there are 3 currently known genotypes : A/A, G/G or A/G
Short Overview
Variant Location
rs12659 is located on gene SLC19A1 in chromsome 21. Use the genome browser to explore the location of rs12659 and its genetic neighbourhood.
Conditions & Traits
rs12659 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs12659.
Pathogenicity
rs12659 affects the following conditions:
There are currently 0 conditions associated with rs12659.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene SLC19A1. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs12659
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs12659 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs12659. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to CARBOPLATIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to CARBOPLATIN.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to CISPLATIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to CISPLATIN.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect to FLUOROURACIL.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to FLUOROURACIL.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to CARBOPLATIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to CARBOPLATIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to CISPLATIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to CISPLATIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect to FLUOROURACIL.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to FLUOROURACIL.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs12659
All drugs that are linked to rs12659 are listed here.
Studies and Sources
All of the resources below examine variant rs12659
Sook Wah Yee, Li Gong, Ilaria Badagnani, Kathleen M. Giacomini, Teri E. Klein, Russ B. Altman
Rubina Tabassum, Alok Jaiswal, Ganesh Chauhan, Om Prakash Dwivedi, Saurabh Ghosh, Raman K. Marwaha, Nikhil Tandon, Dwaipayan Bharadwaj
Tianbo Jin, Xugang Shi, Li Wang, Huijuan Wang, Tian Feng, Longli Kang