Overview

rs11969064 is a genetic variant.

This variant is located on chromosome 6. The variations at position 18104864 are the genetic letters C/C, T/T, C/T

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs11969064 there are 3 currently known genotypes : C/C, T/T or C/T

Short Overview

Variant Location

rs11969064 is located on gene in chromsome 6. Use the genome browser to explore the location of rs11969064 and its genetic neighbourhood.

Conditions & Traits

rs11969064 affects the following conditions and traits:

There are currently 0 conditions and 0 traits associated with rs11969064.

Pathogenicity

rs11969064 affects the following conditions:

There are currently 0 conditions associated with rs11969064.

Pharmacogenetics

rs11969064 affects the following drugs:

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs. Explore more variants and their effects on the body by browsing left and right along the DNA strand.

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Did you know genetic variants affect drugs?

Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.

Dr. Wallerstorfer Dr. Wallerstorfer

Conditions & Traits of rs11969064

Current research shows 0 conditions and 0 traits.

Conditions

0

Pharmacogenetics

The genetic variant rs11969064 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs11969064. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have decreased Side Effects to AZATHIOPRINE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Side Effects to AZATHIOPRINE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Side Effects to AZATHIOPRINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have decreased Side Effects to MERCAPTOPURINE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Side Effects to MERCAPTOPURINE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Side Effects to MERCAPTOPURINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
Level of evidence
Impacts
Summary
CC

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/C have decreased Side Effects to THIOGUANINE.

more info

CT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype C/T have increased Side Effects to THIOGUANINE.

more info

TT

Breakdown

Drug Effect

Side Effects

Dosage

Individuals with the genotype T/T have increased Side Effects to THIOGUANINE.

more info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have decreased Side Effects to AZATHIOPRINE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have increased Side Effects to AZATHIOPRINE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Side Effects to AZATHIOPRINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have decreased Side Effects to MERCAPTOPURINE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have increased Side Effects to MERCAPTOPURINE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Side Effects to MERCAPTOPURINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Genotype
CC
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/C have decreased Side Effects to THIOGUANINE.

Level of evidence

More info

Genotype
CT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype C/T have increased Side Effects to THIOGUANINE.

Level of evidence

More info

Genotype
TT
Impacts

Breakdown

Drug Effect

Side Effects

Dosage

Summary

Individuals with the genotype T/T have increased Side Effects to THIOGUANINE.

Level of evidence

More info

Legend:

Increased

Decreased

No known effect

Drugs related to rs11969064

All drugs that are linked to rs11969064 are listed here.

Studies and Sources

All of the resources below examine variant rs11969064

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease (2/26/19)

Gareth J. Walker, James W. Harrison, Graham A. Heap, Michiel D. Voskuil, Vibeke Andersen, Carl A. Anderson, Ashwin N. Ananthakrishnan, Jeffrey C. Barrett, Laurent Beaugerie, Claire M. Bewshea, Andy T. Cole, Fraser R. Cummings, Mark J. Daly, Pierre Ellul, Richard N. Fedorak, Eleonora A. M. Festen, Timothy H. Florin, Daniel R. Gaya, Jonas Halfvarson, Ailsa L. Hart, Neel M. Heerasing, Peter Hendy, Peter M. Irving, Samuel E. Jones, Jukka Koskela, James O. Lindsay, John C. Mansfield, Dermot McGovern, Miles Parkes, Richard C. G. Pollok, Subramaniam Ramakrishnan, David S. Rampton, Manuel A. Rivas, Richard K. Russell, Michael Schultz, Shaji Sebastian, Philippe Seksik, Abhey Singh, Kenji So, Harry Sokol, Kavitha Subramaniam, Anthony Todd, Vito Annese, Rinse K. Weersma, Ramnik Xavier, Rebecca Ward, Michael N. Weedon, James R. Goodhand, Nicholas A. Kennedy, Tariq Ahmad

PMC: 6439872
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