Overview
rs1127354 is a genetic variant on gene ITPA.
This variant is located on chromosome 20. The variations at position 3213196 are the genetic letters A/A, C/C, G/G, T/T, A/C, C/G, G/T, A/T, A/G, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1127354 there are 10 currently known genotypes : A/A, C/C, G/G, T/T, A/C, C/G, G/T, A/T, A/G or C/T
Short Overview
Variant Location
rs1127354 is located on gene ITPA in chromsome 20. Use the genome browser to explore the location of rs1127354 and its genetic neighbourhood.
Conditions & Traits
rs1127354 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs1127354.
Pathogenicity
rs1127354 affects the following conditions:
There are currently 0 conditions associated with rs1127354.
Pharmacogenetics
rs1127354 affects the following drugs:
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene ITPA. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs1127354
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs1127354 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1127354. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Drug Effect to AZATHIOPRINE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/C have increased Drug Effect to AZATHIOPRINE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to AZATHIOPRINE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Side Effects to MERCAPTOPURINE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/C have increased Side Effects to MERCAPTOPURINE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have decreased Drug Effect and increased Side Effects to METHOTREXATE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/C have decreased Drug Effect and increased Side Effects to METHOTREXATE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect and decreased Side Effects to METHOTREXATE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Drug Effect to AZATHIOPRINE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/C have increased Drug Effect to AZATHIOPRINE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to AZATHIOPRINE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Side Effects to MERCAPTOPURINE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/C have increased Side Effects to MERCAPTOPURINE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have decreased Drug Effect and increased Side Effects to METHOTREXATE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/C have decreased Drug Effect and increased Side Effects to METHOTREXATE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect and decreased Side Effects to METHOTREXATE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs1127354
All drugs that are linked to rs1127354 are listed here.
Studies and Sources
All of the resources below examine variant rs1127354
S Sahana, Ambily Sivadas, Mohit Mangla, Abhinav Jain, Rahul C Bhoyar, Kavita Pandhare, Anushree Mishra, Disha Sharma, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Mercy Rophina, Bani Jolly, Arushi Batra, Sumit Sharma, Sanjay Siwach, Arun G Jadhao, Nikhil V Palande, Ganga Nath Jha, Nishat Ashrafi, Prashant Kumar Mishra, AK Vidhya, Suman Jain, Debasis Dash, Nachimuthu Senthil Kumar, Andrew Vanlallawma, Ranjan Jyoti Sarma, Lalchhandama Chhakchhuak, Shantaraman Kalyanaraman, Radha Mahadevan, Sunitha Kandasamy, Pabitha Devi, Raskin Erusan Rajagopal, J Ezhil Ramya, P Nirmala Devi, Anjali Bajaj, Vishu Gupta, Samatha Mathew, Sangam Goswami, Savinitha Prakash, Kandarp Joshi, Meya Kumla, S Sreedevi, Devarshi Gajjar, Ronibala Soraisham, Rohit Yadav, Yumnam Silla Devi, Aayush Gupta, Mitali Mukerji, Sivaprakash Ramalingam, BK Binukumar, Sridhar Sivasubbu, Vinod Scaria
Qing-Yan Yang, Ya-Hui Hu, Hong-Li Guo, Ying Xia, Yong Zhang, Wei-Rong Fang, Yun-Man Li, Jing Xu, Feng Chen, Yong-Ren Wang, Teng-Fei Wang
Ramón Cacabelos, Vinogran Naidoo, Lola Corzo, Natalia Cacabelos, Juan C. Carril