Overview
rs1126742 is a genetic variant on gene CYP4A11.
This variant is located on chromosome 1. The variations at position 46932824 are the genetic letters A/A, G/G, A/G
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1126742 there are 3 currently known genotypes : A/A, G/G or A/G
Short Overview
Variant Location
rs1126742 is located on gene CYP4A11 in chromsome 1. Use the genome browser to explore the location of rs1126742 and its genetic neighbourhood.
Conditions & Traits
rs1126742 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs1126742.
Pathogenicity
rs1126742 affects the following conditions:
There are currently 0 conditions associated with rs1126742.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene CYP4A11. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs1126742
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs1126742 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1126742. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/A have increased Drug Effect to SPIRONOLACTONE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Drug Effect to SPIRONOLACTONE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have decreased Drug Effect to SPIRONOLACTONE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/A have increased Drug Effect to SPIRONOLACTONE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Drug Effect to SPIRONOLACTONE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have decreased Drug Effect to SPIRONOLACTONE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs1126742
All drugs that are linked to rs1126742 are listed here.
Studies and Sources
All of the resources below examine variant rs1126742
Yoshihiro Kokubo, Sandosh Padmanabhan, Yoshio Iwashima, Kazumasa Yamagishi, Atsushi Goto
Sonia Mota-Zamorano, Nicolás R. Robles, Luz M. González, José M. Valdivielso, Juan Lopez-Gomez, Bárbara Cancho, Guadalupe García-Pino, Guillermo Gervasini
Yunyi Xie, Zheng Liu, Kuo Liu, Han Qi, Wenjuan Peng, Han Cao, Xiaohui Liu, Bingxiao Li, Fuyuan Wen, Fengxu Zhang, Ling Zhang