Overview
rs10494366 is a genetic variant on gene NOS1AP.
This variant is located on chromosome 1. The variations at position 162115895 are the genetic letters C/C, G/G, T/T, C/G, G/T, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs10494366 there are 6 currently known genotypes : C/C, G/G, T/T, C/G, G/T or C/T
Short Overview
Variant Location
rs10494366 is located on gene NOS1AP in chromsome 1. Use the genome browser to explore the location of rs10494366 and its genetic neighbourhood.
Conditions & Traits
rs10494366 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs10494366.
Pathogenicity
rs10494366 affects the following conditions:
There are currently 0 conditions associated with rs10494366.
Pharmacogenetics
rs10494366 affects the following drugs:
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene NOS1AP. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs10494366
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs10494366 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs10494366. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/G have increased Drug Effect to DIGOXIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/T have decreased Drug Effect to DIGOXIN.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Drug Effect to DIGOXIN.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/T have increased Side Effects to GLIMEPIRIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to GLIMEPIRIDE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype G/T have increased Side Effects to GLIPIZIDE.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to GLIPIZIDE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/G have increased Drug Effect to DIGOXIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/T have decreased Drug Effect to DIGOXIN.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Drug Effect to DIGOXIN.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/T have increased Side Effects to GLIMEPIRIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to GLIMEPIRIDE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype G/T have increased Side Effects to GLIPIZIDE.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to GLIPIZIDE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs10494366
All drugs that are linked to rs10494366 are listed here.
Studies and Sources
All of the resources below examine variant rs10494366
Boglárka Marcsa, Réka Dénes, Krisztina Vörös, Gergely Rácz, Mária Sasvári-Székely, Zsolt Rónai, Klára Törő, Gergely Keszler
Iris C.R.M. Kolder, Michael W.T. Tanck, Pieter G. Postema, Julien Barc, Moritz F. Sinner, Sven Zumhagen, Anja Husemann, Birgit Stallmeyer, Tamara T. Koopmann, Nynke Hofman, Arne Pfeufer, Peter Lichtner, Thomas Meitinger, Britt M. Beckmann, Robert J. Myerburg, Nanette H. Bishopric, Dan M. Roden, Stefan Kääb, Arthur A.M. Wilde, Jean-Jacques Schott, Eric Schulze-Bahr, Connie R. Bezzina
Annika Winbo, Eva-Lena Stattin, Ida Maria Westin, Anna Norberg, Johan Persson, Steen M. Jensen, Annika Rydberg