Overview
rs1045280 is a genetic variant on gene ARRB2.
This variant is located on chromosome 17. The variations at position 4719343 are the genetic letters C/C, T/T, C/T
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation combination is referred to as genotype. For variant rs1045280 there are 3 currently known genotypes : C/C, T/T or C/T
Short Overview
Variant Location
rs1045280 is located on gene ARRB2 in chromsome 17. Use the genome browser to explore the location of rs1045280 and its genetic neighbourhood.
Conditions & Traits
rs1045280 affects the following conditions and traits:
There are currently 0 conditions and 0 traits associated with rs1045280.
Pathogenicity
rs1045280 affects the following conditions:
There are currently 0 conditions associated with rs1045280.
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of variant rs on gene ARRB2. Explore more variants and their effects on the body by browsing left and right along the DNA strand.
Did you know genetic variants affect drugs?
Mutations are changes in genes and genetic variations are differences in the DNA among people. Variants are tiny changes in just one piece of the DNA while haplotypes are groups of these changes that usually come together.
Conditions & Traits of rs1045280
Current research shows 0 conditions and 0 traits.
Conditions
0Pharmacogenetics
The genetic variant rs1045280 impacts how certain medications work in the body. This difference may cause some of us to require different dosage amounts to achieve the desired effects, while others might experience more apparent side-effects. As a result, healthcare providers may need to adjust prescriptions for those individuals with rs1045280. Ultimately, understanding our genetic makeup helps improve the overall effectiveness and usability of medications. Tailoring treatments based on genetics ensures a safer, more personalized healthcare experience.
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to BUPRENORPHINE.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Level of evidence
Impacts
Summary
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to FENTANYL.
more info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to BUPRENORPHINE.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
Level of evidence
More info
Genotype
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to FENTANYL.
Level of evidence
More info
Legend:
Increased
Decreased
No known effect
Drugs related to rs1045280
All drugs that are linked to rs1045280 are listed here.
Studies and Sources
All of the resources below examine variant rs1045280
Orna Levran, Einat Peles, Matthew Randesi, Xu Shu, Jurg Ott, Pei-Hong Shen, Miriam Adelson, Mary Jeanne Kreek
Emanuela Scarpi, Daniele Calistri, Pål Klepstad, Stein Kaasa, Frank Skorpen, Ragnhild Habberstad, Oriana Nanni, Dino Amadori, Marco Maltoni
David C Currow, Stephen Quinn, Magnus Ekstrom, Stein Kaasa, Miriam J Johnson, Andrew A Somogyi, Päl Klepstad