Genes
SLCO1B1
This gene is related to these conditions:
Effect of Variations on the SLCO1B1
Variants are common variations in genes that can significantly impact the health and traits of an individual. This section shows all variants that are located on SLCO1B1, as well as their associated conditions, traits and drugs.
Did you know that gene anomalies are relatively common?
On average, each person has approximately 100 to 400 genes with variations or mutations (with different genes being affected in different individuals). However, in most cases, the matching gene on the other chromosome in the pair is normal, which helps prevent potential negative effects. In the general population, the likelihood of an individual inheriting two copies of the same abnormal gene—and thus developing a genetic disorder—is very low. However, this risk increases significantly for children of parents who are closely related by blood.
Dr. Wallerstorfer
Conditions caused and influenced by SLCO1B1
Genetic abnormalities can affect the chance of developing a condition by raising or lowering the risk. They can change how a gene works, leading to faulty or missing proteins. However, even with a higher genetic risk, a condition may not develop because factors like environment and lifestyle also have an impact.
Variants located on SLCO1B1
The genetic code of a gene is virtually identical between differen people. Only a few individual letters differ from one person to the next.
Did you know genetic variations may affect drugs?
Genetic differences can affect how our body reacts to drugs. Some genes can make a drug work better or worse, and others can change how safe it is or how much of it you need.
Dr. Wallerstorfer
Pharmacogenetics
Genetic differences can affect how our bodies respond to medications. Some people’s genes can make a drug work better or worse, change how safe it is, or influence how much of the drug they need. These genetic changes can affect how the body processes medicine, like how quickly it is broken down or how it interacts with cells. For example, a genetic difference might cause a person’s body to break down a drug too fast, making it less effective, or too slowly, increasing the risk of side effects. This is why people can have different reactions to the same medication.
rs2291075
Drug
Genotype
Level of evidence
Impacts
Summary
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect to CYTARABINE.
more info
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to CYTARABINE.
more info
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Drug Effect to CYTARABINE.
more info
DAUNORUBICIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect to DAUNORUBICIN.
more info
DAUNORUBICIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to DAUNORUBICIN.
more info
DAUNORUBICIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Drug Effect to DAUNORUBICIN.
more info
ETOPOSIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect to ETOPOSIDE.
more info
ETOPOSIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to ETOPOSIDE.
more info
ETOPOSIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Drug Effect to ETOPOSIDE.
more info
Legend:
Increased
Decreased
No known effect
rs2306283
Drug
Genotype
Level of evidence
Impacts
Summary
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype A/G have increased Dosage to METHOTREXATE.
more info
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
rs4149056
Drug
Genotype
Level of evidence
Impacts
Summary
AMPRENAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
AMPRENAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
AMPRENAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
CYCLOPHOSPHAMIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to CYCLOPHOSPHAMIDE.
more info
CYCLOPHOSPHAMIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to CYCLOPHOSPHAMIDE.
more info
CYCLOPHOSPHAMIDE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to CYCLOPHOSPHAMIDE.
more info
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Side Effects to CYTARABINE.
more info
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Side Effects to CYTARABINE.
more info
CYTARABINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Side Effects to CYTARABINE.
more info
DOCETAXEL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to DOCETAXEL.
more info
DOCETAXEL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to DOCETAXEL.
more info
DOCETAXEL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to DOCETAXEL.
more info
FLUOROURACIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Drug Effect to FLUOROURACIL.
more info
FLUOROURACIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect to FLUOROURACIL.
more info
FLUOROURACIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to FLUOROURACIL.
more info
LOPINAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
LOPINAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
LOPINAVIR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
LOVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Side Effects to LOVASTATIN.
more info
LOVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Side Effects to LOVASTATIN.
more info
LOVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Side Effects to LOVASTATIN.
more info
MERCAPTOPURINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Dosage to MERCAPTOPURINE.
more info
MERCAPTOPURINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have decreased Dosage to MERCAPTOPURINE.
more info
MERCAPTOPURINE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Dosage to MERCAPTOPURINE.
more info
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Drug Effect, decreased Breakdown and decreased Dosage to METHOTREXATE.
more info
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Drug Effect, decreased Breakdown and decreased Dosage to METHOTREXATE.
more info
METHOTREXATE
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Drug Effect, increased Breakdown and increased Dosage to METHOTREXATE.
more info
MYCOPHENOLATE MOFETIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Side Effects to MYCOPHENOLATE MOFETIL.
more info
MYCOPHENOLATE MOFETIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Side Effects to MYCOPHENOLATE MOFETIL.
more info
MYCOPHENOLATE MOFETIL
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have increased Side Effects to MYCOPHENOLATE MOFETIL.
more info
SIMVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have increased Side Effects to SIMVASTATIN.
more info
SIMVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/T have increased Side Effects to SIMVASTATIN.
more info
SIMVASTATIN
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype T/T have decreased Side Effects to SIMVASTATIN.
more info
TICAGRELOR
Breakdown
Drug Effect
Side Effects
Dosage
Individuals with the genotype C/C have decreased Breakdown and decreased Dosage to TICAGRELOR.
more info
TICAGRELOR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
TICAGRELOR
Breakdown
Drug Effect
Side Effects
Dosage
No summary available.
more info
Legend:
Increased
Decreased
No known effect
rs2291075
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect to CYTARABINE.
More info
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to CYTARABINE.
More info
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Drug Effect to CYTARABINE.
More info
Drug
DAUNORUBICIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect to DAUNORUBICIN.
More info
Drug
DAUNORUBICIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to DAUNORUBICIN.
More info
Drug
DAUNORUBICIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Drug Effect to DAUNORUBICIN.
More info
Drug
ETOPOSIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect to ETOPOSIDE.
More info
Drug
ETOPOSIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to ETOPOSIDE.
More info
Drug
ETOPOSIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Drug Effect to ETOPOSIDE.
More info
Legend:
Increased
Decreased
No known effect
rs2306283
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype A/G have increased Dosage to METHOTREXATE.
More info
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Legend:
Increased
Decreased
No known effect
rs4149056
Drug
AMPRENAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
AMPRENAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
AMPRENAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
CYCLOPHOSPHAMIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to CYCLOPHOSPHAMIDE.
More info
Drug
CYCLOPHOSPHAMIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to CYCLOPHOSPHAMIDE.
More info
Drug
CYCLOPHOSPHAMIDE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to CYCLOPHOSPHAMIDE.
More info
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Side Effects to CYTARABINE.
More info
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Side Effects to CYTARABINE.
More info
Drug
CYTARABINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Side Effects to CYTARABINE.
More info
Drug
DOCETAXEL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to DOCETAXEL.
More info
Drug
DOCETAXEL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to DOCETAXEL.
More info
Drug
DOCETAXEL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to DOCETAXEL.
More info
Drug
FLUOROURACIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Drug Effect to FLUOROURACIL.
More info
Drug
FLUOROURACIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect to FLUOROURACIL.
More info
Drug
FLUOROURACIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to FLUOROURACIL.
More info
Drug
LOPINAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
LOPINAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
LOPINAVIR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
LOVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Side Effects to LOVASTATIN.
More info
Drug
LOVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Side Effects to LOVASTATIN.
More info
Drug
LOVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Side Effects to LOVASTATIN.
More info
Drug
MERCAPTOPURINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Dosage to MERCAPTOPURINE.
More info
Drug
MERCAPTOPURINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have decreased Dosage to MERCAPTOPURINE.
More info
Drug
MERCAPTOPURINE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Dosage to MERCAPTOPURINE.
More info
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Drug Effect, decreased Breakdown and decreased Dosage to METHOTREXATE.
More info
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Drug Effect, decreased Breakdown and decreased Dosage to METHOTREXATE.
More info
Drug
METHOTREXATE
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Drug Effect, increased Breakdown and increased Dosage to METHOTREXATE.
More info
Drug
MYCOPHENOLATE MOFETIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Side Effects to MYCOPHENOLATE MOFETIL.
More info
Drug
MYCOPHENOLATE MOFETIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Side Effects to MYCOPHENOLATE MOFETIL.
More info
Drug
MYCOPHENOLATE MOFETIL
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have increased Side Effects to MYCOPHENOLATE MOFETIL.
More info
Drug
SIMVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have increased Side Effects to SIMVASTATIN.
More info
Drug
SIMVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/T have increased Side Effects to SIMVASTATIN.
More info
Drug
SIMVASTATIN
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype T/T have decreased Side Effects to SIMVASTATIN.
More info
Drug
TICAGRELOR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
Individuals with the genotype C/C have decreased Breakdown and decreased Dosage to TICAGRELOR.
More info
Drug
TICAGRELOR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Drug
TICAGRELOR
Genotype
Level of evidence
Impacts
Breakdown
Drug Effect
Side Effects
Dosage
Summary
No summary available.
More info
Legend:
Increased
Decreased
No known effect