The ANKRD60 gene helps make a protein in the ankyrin repeat family, which usually supports how proteins connect and communicate inside cells. If this gene does not work as expected, those cell signals may be less coordinated, which can influence growth and development. Research has linked variants in or near the ANKRD60 gene to differences in height and body growth in some people. Most variants are likely to have little or no effect, while a few may play a role in health or physical traits.
What is a gene?
A gene is a section of DNA that holds instructions your cells use to make molecules or regulate processes in the body. Some genes carry the instructions for producing proteins, which are the parts of cells that do much of the work. Other genes are mainly involved in controlling when certain processes happen, where they happen, and how active they are. Taken together, genes affect how the body grows and works, and they can also influence how you respond to food, stress, or medications. To go deeper into this topic, you can read more in the LearnHub.
Overview
ANKRD60Gene function
What if the gene works
The ANKRD60 gene gives cells instructions for making a protein with ankyrin repeats, a structure that helps proteins connect with each other. This likely supports routine cell communication and control.
Risk
What if the gene does not work
Variants in the ANKRD60 gene can range from milder to more severe and may partly reduce, or nearly eliminate, the ANKRD60 protein. This can disrupt its interactions with other proteins and the cell processes it helps support.
Treatment
What does that mean for your treatment
No treatment or drug choice based on pathogenic variants in the ANKRD60 gene is currently established in clinical guidelines.
Gene function
What if the gene works
Inside your cells, the ANKRD60 gene helps make a protein with ankyrin repeat sections. These sections serve as docking surfaces that support routine protein contacts. This helps cells carry out everyday tasks in an organized way.
The ANKRD60 gene provides instructions for making the ANKRD60 protein. When it is working normally, your cells can produce this protein as part of routine cell activity.
Ankyrin repeat sections in the ANKRD60 protein are shaped to help proteins attach to other proteins. Understanding how the ANKRD60 gene works starts with these everyday protein contacts inside cells.
What is a variant?
A genetic variant is a small difference in the DNA sequence of a gene. These differences are common and help create normal human diversity, including differences in appearance, metabolism, or how the body responds to environmental influences. Many variants do not have any noticeable effect and simply represent natural genetic variation. In some situations, however, a variant can change how a gene functions more significantly and may contribute to or cause a genetic condition.
Genetic variants
What if the gene does not work
How variants in the ANKRD60 gene affect protein function depends on the type of DNA change. Some variants swap a single protein building block and may have a mild effect, while more severe variants can shift the reading frame or create an early stop signal, leaving a shortened protein. These changes can reduce protein stability or weaken its interactions with other proteins inside the cell.
How variants are linked to conditions
The ANKRD60 gene does not yet have a broadly confirmed link to a specific health condition, though this may change as research develops. Information on ANKRD60 gene variants and health conditions is still evolving, so anyone with a confirmed ANKRD60-related diagnosis should rely on guidance from their doctor or genetic counselor.
A variant is not necessarily a diagnosis
Genetic variants are a routine part of human biology and are widely seen across the general population. Most do not have a direct effect on health and simply reflect natural human diversity. For many genes, carrying a variant associated with a condition suggests a possible link rather than a definite diagnosis, especially when several genes and environmental factors contribute. In some situations, though, a single well-characterized variant in a particular gene can be enough to confirm a diagnosis.
Are there things that can increase or change my risk?
There is not yet broadly confirmed evidence on specific factors that increase or reduce health risk related to the ANKRD60 gene. If ANKRD60 is mentioned in your test results, a doctor or genetic counselor can help explain what it may mean in the context of your personal and family history.
Inheritance of ANKRD60 variants
There is not yet a broadly confirmed, disease-specific Mendelian pattern for ANKRD60 gene inheritance, so ANKRD60 variants are not currently described as following a clearly established autosomal dominant, autosomal recessive, or X-linked condition in routine clinical genetics. This picture may become clearer as research develops. The ANKRD60 gene is located on chromosome 19, which is an autosome, so you inherit one copy of this gene from each parent.
What does my ANKRD60 result mean for my family?
There isn't yet a broadly confirmed inheritance pattern tied to a specific condition for ANKRD60, though this understanding can change as research develops. If you have a specific ANKRD60 result and questions about what it could mean for your family, a doctor or genetic counselor can explain it in the context of your personal and family history.
Genetic information
Genetic testing
How you find out about variants
Variants in the ANKRD60 gene are found through genetic testing that reads your DNA, usually from a blood sample or cheek swab. In practice, how you find out about variants in the ANKRD60 gene is through a multigene panel, exome sequencing, or genome sequencing, which compares the gene’s sequence with a reference to look for changes.
When should I consider getting a genetic test?
There is not yet a broadly established reason to get ANKRD60 genetic testing on its own in routine care. Testing decisions are usually based on your personal health history, symptoms, and family history, often with guidance from a doctor or genetic counselor.
A genetic result is only one part of your health story
A genetic result can provide meaningful insight, but how much it explains varies by the condition and the type of variant involved. How the body works over time is also shaped by factors such as lifestyle, environment, age, and medical history. For some conditions, especially those influenced by many genes, genetic information offers context rather than certainty and is most useful when considered alongside other parts of care. In other situations, a genetic result may give a clear answer. In areas like medication response, genetic results can also help put individual experiences into context.
Pharmacogenetics
How variants shape your response to medicine
Genetic variation can affect how people respond to medicines. This helps explain why the same treatment works well for one person, seems weaker for another, or causes more side effects in someone else. Small differences in how the body breaks down, moves, or responds to a drug are common, and they can influence both benefit and sensitivity.
What is Pharmacogenetics?
Pharmacogenetics examines how genetic differences affect the way people respond to medications. It looks at gene and drug patterns to help explain why the same treatment may work differently from one person to another. For many medicines, genes influence how strongly a drug works or how the body handles it. This understanding can help support treatment decisions that are more informed and more individualized. To explore this topic further, more information is available in the LearnHub.
Drugs influenced by the ANKRD60 gene
When should I seek medical advice?
There is not yet a broadly confirmed role for this gene in predicting how medicines will work, so questions about treatment, side effects, or changes in how you feel are best discussed with your doctor.