Genetic variation
rs6265
Overview
SNPs are specific locations in the DNA where genetic variations can occur. Every person has a unique composition of variations.
SNP rs6265 is located on chromosome 11. The most common variation at this position is the C. People with other variations might have letter T instead.
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation assembly is referred to as genotype. For SNP rs6265 there are 3 currently known genotypes: A/G , A/A or G/G
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of SNP rs6265. Explore more SNPs and their effects on the body by browsing left and right along the DNA strand.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
XX
Mitochondrial DNAEffects relating to rs6265
Your genetic code influences you in many ways. This may be by either causing you to have a specific trait (eg. Eye colour) or your risk of developing a specific disease.
Each combination of genetic letters (called bases) is called a genotype for this specific SNP. Each Genotype can have a different effect on your body. The table below shows which genotype causes which traits or disease risks.
Current research shows 7 disease risks associated with rs6265. The following table shows the relationship between genotype and .
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Migraine | 1.22x | ||
Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case–Control Studies (2017) Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina Text Extract:When stratified by migraine type, a similar trend of association was detected with both MA and MO, but a statistically significant association of rs6265 was reached only with the MA subtype in the dominant model (OR: 1.22, 95% CI: 1.001.47, p=0.047) PMCID: PMCID5410590 | |||
| Depression | 0.62x | ||
Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients (2020) Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A. Text Extract:Categorizing HAMD-17 into high and low groups did not result in a similar significant effect for rs6265 (likely due to the limited number of depressed subjects with two minor alleles) (Figure 2), and neither did the odds ratio (OR) for depressed versus healthy: 0.62 (95%CI 0.35; 1.11; p = 0.110) PMCID: PMCID7028755 | |||
| Parkinson's disease | 2.83x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of PD development (p = 6.7 103), with OR = 2.83, 95% CI [1.276.29] PMCID: PMCID8706187 | |||
| Impulsive–compulsive and related behavioral disorders (ICD) | 4.49x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of ICD development (p = 5.7 106), with an estimate of OR = 4.49, 95% CI [2.249.18] PMCID: PMCID8706187 | |||
| Attention deficit and hyperactivity disorder (ADHD) | 0.95x | ||
Evaluation of the Relationship Between BDNF Val66Met Gene Polymorphism and Attention Deficit Hyperactivity Disorder: A Meta-Analysis (2022) Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun Text Extract:Fifteen studies, comprising of 8,692 samples (containing 4,364 cases, 4,328 controls) and 1,578 families were included and results demonstrated that rs6265 was not associated with susceptibility to ADHD (OR = 0.95, 95% CI: 0.871.04, P = 0.291) PMCID: PMCID9096026 | |||
| Asthma | 1.43x | ||
Association between brain-derived neurothropic factor variants and asthma in Chinese Han children. (2013) Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang Text Extract:The participants, recruited between May 2009 and July 2012, were 319 children with asthma (mean age 9.82 ± 1.57 years) recruited from a hospital paediatric department and 309 healthy controls (mean age 10.25 ± 1.36 years), recruited from the medical examination centre at the same hospital.We observed a significant association for rs6265 (χ(2) = 9.851, p = 0.002, OR = 1.427, 95% CI = 1.143-1.783), located in exon 4 of the BDNF PMID: PMID23461616 | |||
| Coronary artery disease with depression (CAD-D) | 1.49x | ||
Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response. (2015) Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie Text Extract:The results demonstrated that a significant association existed between the SNP rs6265, located in exon 4 of the BDNF gene, and CAD‑D [χ2=9.634, P=0.002, odds ratio (OR)=1.486, 95% confidence interval (CI)=1.156‑1.910] PMID: PMID25324022 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Migraine | 1.00x | ||
Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case–Control Studies (2017) Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina Text Extract:When stratified by migraine type, a similar trend of association was detected with both MA and MO, but a statistically significant association of rs6265 was reached only with the MA subtype in the dominant model (OR: 1.22, 95% CI: 1.001.47, p=0.047) PMCID: PMCID5410590 | |||
| Depression | 1.00x | ||
Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients (2020) Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A. Text Extract:Categorizing HAMD-17 into high and low groups did not result in a similar significant effect for rs6265 (likely due to the limited number of depressed subjects with two minor alleles) (Figure 2), and neither did the odds ratio (OR) for depressed versus healthy: 0.62 (95%CI 0.35; 1.11; p = 0.110) PMCID: PMCID7028755 | |||
| Parkinson's disease | 4.66x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of PD development (p = 6.7 103), with OR = 2.83, 95% CI [1.276.29] PMCID: PMCID8706187 | |||
| Impulsive–compulsive and related behavioral disorders (ICD) | 7.98x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of ICD development (p = 5.7 106), with an estimate of OR = 4.49, 95% CI [2.249.18] PMCID: PMCID8706187 | |||
| Attention deficit and hyperactivity disorder (ADHD) | 1.00x | ||
Evaluation of the Relationship Between BDNF Val66Met Gene Polymorphism and Attention Deficit Hyperactivity Disorder: A Meta-Analysis (2022) Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun Text Extract:Fifteen studies, comprising of 8,692 samples (containing 4,364 cases, 4,328 controls) and 1,578 families were included and results demonstrated that rs6265 was not associated with susceptibility to ADHD (OR = 0.95, 95% CI: 0.871.04, P = 0.291) PMCID: PMCID9096026 | |||
| Asthma | 1.00x | ||
Association between brain-derived neurothropic factor variants and asthma in Chinese Han children. (2013) Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang Text Extract:The participants, recruited between May 2009 and July 2012, were 319 children with asthma (mean age 9.82 ± 1.57 years) recruited from a hospital paediatric department and 309 healthy controls (mean age 10.25 ± 1.36 years), recruited from the medical examination centre at the same hospital.We observed a significant association for rs6265 (χ(2) = 9.851, p = 0.002, OR = 1.427, 95% CI = 1.143-1.783), located in exon 4 of the BDNF PMID: PMID23461616 | |||
| Coronary artery disease with depression (CAD-D) | 1.00x | ||
Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response. (2015) Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie Text Extract:The results demonstrated that a significant association existed between the SNP rs6265, located in exon 4 of the BDNF gene, and CAD‑D [χ2=9.634, P=0.002, odds ratio (OR)=1.486, 95% confidence interval (CI)=1.156‑1.910] PMID: PMID25324022 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Migraine | 1.44x | ||
Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case–Control Studies (2017) Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina Text Extract:When stratified by migraine type, a similar trend of association was detected with both MA and MO, but a statistically significant association of rs6265 was reached only with the MA subtype in the dominant model (OR: 1.22, 95% CI: 1.001.47, p=0.047) PMCID: PMCID5410590 | |||
| Depression | 0.38x | ||
Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients (2020) Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A. Text Extract:Categorizing HAMD-17 into high and low groups did not result in a similar significant effect for rs6265 (likely due to the limited number of depressed subjects with two minor alleles) (Figure 2), and neither did the odds ratio (OR) for depressed versus healthy: 0.62 (95%CI 0.35; 1.11; p = 0.110) PMCID: PMCID7028755 | |||
| Parkinson's disease | 1.00x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of PD development (p = 6.7 103), with OR = 2.83, 95% CI [1.276.29] PMCID: PMCID8706187 | |||
| Impulsive–compulsive and related behavioral disorders (ICD) | 1.00x | ||
Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy (2021) Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene Text Extract:The dominant Allele A of the rs6265 substitution increases the risk of ICD development (p = 5.7 106), with an estimate of OR = 4.49, 95% CI [2.249.18] PMCID: PMCID8706187 | |||
| Attention deficit and hyperactivity disorder (ADHD) | 0.90x | ||
Evaluation of the Relationship Between BDNF Val66Met Gene Polymorphism and Attention Deficit Hyperactivity Disorder: A Meta-Analysis (2022) Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun Text Extract:Fifteen studies, comprising of 8,692 samples (containing 4,364 cases, 4,328 controls) and 1,578 families were included and results demonstrated that rs6265 was not associated with susceptibility to ADHD (OR = 0.95, 95% CI: 0.871.04, P = 0.291) PMCID: PMCID9096026 | |||
| Asthma | 1.85x | ||
Association between brain-derived neurothropic factor variants and asthma in Chinese Han children. (2013) Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang Text Extract:The participants, recruited between May 2009 and July 2012, were 319 children with asthma (mean age 9.82 ± 1.57 years) recruited from a hospital paediatric department and 309 healthy controls (mean age 10.25 ± 1.36 years), recruited from the medical examination centre at the same hospital.We observed a significant association for rs6265 (χ(2) = 9.851, p = 0.002, OR = 1.427, 95% CI = 1.143-1.783), located in exon 4 of the BDNF PMID: PMID23461616 | |||
| Coronary artery disease with depression (CAD-D) | 1.97x | ||
Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response. (2015) Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie Text Extract:The results demonstrated that a significant association existed between the SNP rs6265, located in exon 4 of the BDNF gene, and CAD‑D [χ2=9.634, P=0.002, odds ratio (OR)=1.486, 95% confidence interval (CI)=1.156‑1.910] PMID: PMID25324022 | |||
Distribution
Knowing your genome can actually tell you a lot about your ancestors.
The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.
This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.
At present, there is no distribution data available for SNP rs6265.
Studies and sources
All of the resources below examine SNP rs6265
Genotype
Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina
Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A.
Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene
Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun
Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang
Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie
Genotype
Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina
Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A.
Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene
Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun
Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang
Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie
Genotype
Terrazzino, Salvatore, Cargnin, Sarah, Viana, Michele, Sances, Grazia, Tassorelli, Cristina
Losenkov, Innokentiy S., Mulder, Nathaniël J. V., Levchuk, Lyudmila A., Vyalova, Natalya M., Loonen, Anton J. M., Bosker, Fokko J., Simutkin, German G., Boiko, Anastasiia S., Bokhan, Nikolay A., Wilffert, Bob, Hak, Eelko, Schmidt, Amand F., Ivanova, Svetlana A.
Fedosova, Anna, Titova, Nataliya, Kokaeva, Zarema, Shipilova, Natalia, Katunina, Elena, Klimov, Eugene
Mei, Shufang, Chen, Wencai, Chen, Sijing, Hu, Yani, Dai, Xiaoyan, Liu, Xiujun
Yinli, Cao, Jie, Hao, Li, Zhao, Jun, Gao, Peiling, Li, Weihong, Yang
Liu, Yong-Qiang, Su, Guo-Bao, Duan, Chang-Hong, Wang, Jun-Hua, Liu, Hai-Mei, Feng, Nan, Wang, Qing-Xi, Liu, Xu-En, Zhang, Jie