rs4680

In the DPP, the rs4680 val allele was borderline associated with lower diabetes incidence among participants randomized to metformin (HR = 0.81 [0.651.00], p = 0.05)

However, the P-value of the statistical test of high quality studies was very close to the borderline and it showed a strong association between COMT polymorphism rs4680 and aggression in this recessive gene model (OR =2.10, P=0.064)

In the replication cohort, mothers with the COMT rs4680 G allele had infants with a reduced risk for treatment with 2 medications for NAS (adjusted OR=0.5, p=0.04), meeting point-wise significance

Obviously higher frequency of rs4680 A allele has been discovered in case group (P=.042), demonstrated a positive association with the risk of endometriosis (OR=1.450, 95% CI=1.0122.076)

Among those diagnosed with FM, African-Americans had 11.3 times increased odds of having a COMT diplotype corresponding to high pain sensitivity than low pain sensitivity, regardless of whether or not they were diagnosed with FM (p=7.2710249, adjusted for sex and age) Studies examining the association between COMT and fibromyalgia have largely focused on a single functional polymorphism, rs4680 or val158met, [17, 18, 21] which reduces enzymatic activity by 3- to 4-fold, and is associated with an increased risk of chronic pain [19, 23, 4044]

Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81, 95% CI 0.67-0.98, P = 0.03)

Schizophrenic subjects homozygous for the Met allele at rs4680 doubled the probability of lifetime prevalence of cannabis use in comparison to Val homozygous (Mantel-Haenszel OR=2.07, 95% CI: 1.27-3.26, P=0.0031, in the combined sample)

As for COMT Val158Met (rs4680) polymorphism, the heterogeneous genotype showed a decreased risk for endometrial cancer compared with the common homogenous genotype in a fixed-effect model in Asian population (Met/Val vs. Val/Val: pooled OR, 0.83; 95% CI, 0.70-0.98; P = 0.033; I = 29.2%), whereas no positive results are found in other subgroups or models.COMT Val158Met was seen to show a decreased risk for endometrial cancer in Asian population

In addition, carriers of the STin2 VNTR short allele were found at higher odds for the composite poor outcome including unsuccessful withdrawal therapy and relapse within 12 months of follow-up after successful detoxification (OR 2.81, 95%CI 1.26-6.25, P = 0.009).Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the identification of MOH patients at higher risk of poor prognosis after drug withdrawal.© 2014 The Author(s) European Journal of Neurology © 2014 EAN

Additionally, a significant association was observed between the GRS and loss of control over eating in the total sample (OR: 1.62, CI 95%: 1.01-2.61, p = 0.046).The COMT variant (rs4680) was associated with poor appetite/undereating

In the DPP, the rs4680 val allele was borderline associated with lower diabetes incidence among participants randomized to metformin (HR = 0.81 [0.651.00], p = 0.05)

However, the P-value of the statistical test of high quality studies was very close to the borderline and it showed a strong association between COMT polymorphism rs4680 and aggression in this recessive gene model (OR =2.10, P=0.064)

In the replication cohort, mothers with the COMT rs4680 G allele had infants with a reduced risk for treatment with 2 medications for NAS (adjusted OR=0.5, p=0.04), meeting point-wise significance

Obviously higher frequency of rs4680 A allele has been discovered in case group (P=.042), demonstrated a positive association with the risk of endometriosis (OR=1.450, 95% CI=1.0122.076)

Among those diagnosed with FM, African-Americans had 11.3 times increased odds of having a COMT diplotype corresponding to high pain sensitivity than low pain sensitivity, regardless of whether or not they were diagnosed with FM (p=7.2710249, adjusted for sex and age) Studies examining the association between COMT and fibromyalgia have largely focused on a single functional polymorphism, rs4680 or val158met, [17, 18, 21] which reduces enzymatic activity by 3- to 4-fold, and is associated with an increased risk of chronic pain [19, 23, 4044]

Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81, 95% CI 0.67-0.98, P = 0.03)

Schizophrenic subjects homozygous for the Met allele at rs4680 doubled the probability of lifetime prevalence of cannabis use in comparison to Val homozygous (Mantel-Haenszel OR=2.07, 95% CI: 1.27-3.26, P=0.0031, in the combined sample)

As for COMT Val158Met (rs4680) polymorphism, the heterogeneous genotype showed a decreased risk for endometrial cancer compared with the common homogenous genotype in a fixed-effect model in Asian population (Met/Val vs. Val/Val: pooled OR, 0.83; 95% CI, 0.70-0.98; P = 0.033; I = 29.2%), whereas no positive results are found in other subgroups or models.COMT Val158Met was seen to show a decreased risk for endometrial cancer in Asian population

In addition, carriers of the STin2 VNTR short allele were found at higher odds for the composite poor outcome including unsuccessful withdrawal therapy and relapse within 12 months of follow-up after successful detoxification (OR 2.81, 95%CI 1.26-6.25, P = 0.009).Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the identification of MOH patients at higher risk of poor prognosis after drug withdrawal.© 2014 The Author(s) European Journal of Neurology © 2014 EAN

Additionally, a significant association was observed between the GRS and loss of control over eating in the total sample (OR: 1.62, CI 95%: 1.01-2.61, p = 0.046).The COMT variant (rs4680) was associated with poor appetite/undereating

Analysis of pooled ORs and 95% CIs suggested that the AA genotype of COMT(rs4680) was associated with LID (OR = 1.39, 95%CI: 1.02-1.89, P = 0.039) in the recessive model, and this correlation was more obvious in Brazilian samples in the analysis stratified by ethnicity

In the DPP, the rs4680 val allele was borderline associated with lower diabetes incidence among participants randomized to metformin (HR = 0.81 [0.651.00], p = 0.05)

However, the P-value of the statistical test of high quality studies was very close to the borderline and it showed a strong association between COMT polymorphism rs4680 and aggression in this recessive gene model (OR =2.10, P=0.064)

In the replication cohort, mothers with the COMT rs4680 G allele had infants with a reduced risk for treatment with 2 medications for NAS (adjusted OR=0.5, p=0.04), meeting point-wise significance

Obviously higher frequency of rs4680 A allele has been discovered in case group (P=.042), demonstrated a positive association with the risk of endometriosis (OR=1.450, 95% CI=1.0122.076)

Among those diagnosed with FM, African-Americans had 11.3 times increased odds of having a COMT diplotype corresponding to high pain sensitivity than low pain sensitivity, regardless of whether or not they were diagnosed with FM (p=7.2710249, adjusted for sex and age) Studies examining the association between COMT and fibromyalgia have largely focused on a single functional polymorphism, rs4680 or val158met, [17, 18, 21] which reduces enzymatic activity by 3- to 4-fold, and is associated with an increased risk of chronic pain [19, 23, 4044]

Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81, 95% CI 0.67-0.98, P = 0.03)

Schizophrenic subjects homozygous for the Met allele at rs4680 doubled the probability of lifetime prevalence of cannabis use in comparison to Val homozygous (Mantel-Haenszel OR=2.07, 95% CI: 1.27-3.26, P=0.0031, in the combined sample)

As for COMT Val158Met (rs4680) polymorphism, the heterogeneous genotype showed a decreased risk for endometrial cancer compared with the common homogenous genotype in a fixed-effect model in Asian population (Met/Val vs. Val/Val: pooled OR, 0.83; 95% CI, 0.70-0.98; P = 0.033; I = 29.2%), whereas no positive results are found in other subgroups or models.COMT Val158Met was seen to show a decreased risk for endometrial cancer in Asian population

In addition, carriers of the STin2 VNTR short allele were found at higher odds for the composite poor outcome including unsuccessful withdrawal therapy and relapse within 12 months of follow-up after successful detoxification (OR 2.81, 95%CI 1.26-6.25, P = 0.009).Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the identification of MOH patients at higher risk of poor prognosis after drug withdrawal.© 2014 The Author(s) European Journal of Neurology © 2014 EAN

Additionally, a significant association was observed between the GRS and loss of control over eating in the total sample (OR: 1.62, CI 95%: 1.01-2.61, p = 0.046).The COMT variant (rs4680) was associated with poor appetite/undereating

Analysis of pooled ORs and 95% CIs suggested that the AA genotype of COMT(rs4680) was associated with LID (OR = 1.39, 95%CI: 1.02-1.89, P = 0.039) in the recessive model, and this correlation was more obvious in Brazilian samples in the analysis stratified by ethnicity