Overview

SNPs are specific locations in the DNA where genetic variations can occur. Every person has a unique composition of variations.

SNP rs35356162 is located on chromosome 6. The most common variation at this position is the G. People with other variations might have letter T instead.

Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation assembly is referred to as genotype. For SNP rs35356162 there are 3 currently known genotypes: G/T , T/T or G/G

Genome Browser

This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of SNP rs35356162. Explore more SNPs and their effects on the body by browsing left and right along the DNA strand.

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Mitochondrial DNAMitochondrial DNA
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Effects relating to rs35356162

Your genetic code influences you in many ways. This may be by either causing you to have a specific trait (eg. Eye colour) or your risk of developing a specific disease.

Each combination of genetic letters (called bases) is called a genotype for this specific SNP. Each Genotype can have a different effect on your body. The table below shows which genotype causes which traits or disease risks.

Current research shows 1 disease risks associated with rs35356162. The following table shows the relationship between genotype and .



Genotype GT

Effect Likelihood Level of evidenceResearch
Bladder cancer (BCa)
4.33x
The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

Text Extract:

However, combined analysis after Bonferroni adjustment showed that only UHRF1BP1 rs35356162 (OR = 4.332, 95% CI: 2.463 7.619, P = 3.62E-07 <7.93E-07) was identified as independent variant significantly associated with BCa risk in Han Chinese (Table 2)

PMCID: PMCID7026461
Read on PMC
Legend:
Increased probability
Decreased probability
No known effect

Genotype TT

Effect Likelihood Level of evidenceResearch
Bladder cancer (BCa)
1.00x
The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

Text Extract:

However, combined analysis after Bonferroni adjustment showed that only UHRF1BP1 rs35356162 (OR = 4.332, 95% CI: 2.463 7.619, P = 3.62E-07 <7.93E-07) was identified as independent variant significantly associated with BCa risk in Han Chinese (Table 2)

PMCID: PMCID7026461
Read on PMC
Legend:
Increased probability
Decreased probability
No known effect

Genotype GG

Effect Likelihood Level of evidenceResearch
Bladder cancer (BCa)
7.66x
The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

Text Extract:

However, combined analysis after Bonferroni adjustment showed that only UHRF1BP1 rs35356162 (OR = 4.332, 95% CI: 2.463 7.619, P = 3.62E-07 <7.93E-07) was identified as independent variant significantly associated with BCa risk in Han Chinese (Table 2)

PMCID: PMCID7026461
Read on PMC
Legend:
Increased probability
Decreased probability
No known effect

Distribution

Knowing your genome can actually tell you a lot about your ancestors.

The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.

This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.

At present, there is no distribution data available for SNP rs35356162.

Studies and sources

All of the resources below examine SNP rs35356162

Genotype GT

The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

PMCID: PMCID7026461

Genotype TT

The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

PMCID: PMCID7026461

Genotype GG

The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population (2020)

Wu, Junlong, Wang, Meilin, Chen, Haitao, Xu, Jianfeng, Zhang, Guiming, Gu, Chengyuan, Ding, Qiang, Wei, Qingyi, Zhu, Yao, Ye, Dingwei

PMCID: PMCID7026461