Genetic variation
rs2787486
Overview
SNPs are specific locations in the DNA where genetic variations can occur. Every person has a unique composition of variations.
SNP rs2787486 is located on chromosome 17. The most common variation at this position is the A. People with other variations might have letter C instead.
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation assembly is referred to as genotype. For SNP rs2787486 there are 3 currently known genotypes: A/T , A/A or T/T
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of SNP rs2787486. Explore more SNPs and their effects on the body by browsing left and right along the DNA strand.
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Mitochondrial DNAEffects relating to rs2787486
Your genetic code influences you in many ways. This may be by either causing you to have a specific trait (eg. Eye colour) or your risk of developing a specific disease.
Each combination of genetic letters (called bases) is called a genotype for this specific SNP. Each Genotype can have a different effect on your body. The table below shows which genotype causes which traits or disease risks.
Current research shows 1 disease risks associated with rs2787486. The following table shows the relationship between genotype and .
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| ER disease | 1.19x | ||
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) (2016) Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M. Text Extract:The most strongly associated SNP for ER disease was c17_pos53079506 (OR=1.19 (1.071.33), P=0.0017, =0.015) located ~130kb from rs2787486 PMCID: PMCID5013272 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| ER disease | 1.00x | ||
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) (2016) Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M. Text Extract:The most strongly associated SNP for ER disease was c17_pos53079506 (OR=1.19 (1.071.33), P=0.0017, =0.015) located ~130kb from rs2787486 PMCID: PMCID5013272 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| ER disease | 1.38x | ||
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) (2016) Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M. Text Extract:The most strongly associated SNP for ER disease was c17_pos53079506 (OR=1.19 (1.071.33), P=0.0017, =0.015) located ~130kb from rs2787486 PMCID: PMCID5013272 | |||
Distribution
Knowing your genome can actually tell you a lot about your ancestors.
The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.
This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.
At present, there is no distribution data available for SNP rs2787486.
Studies and sources
All of the resources below examine SNP rs2787486
Genotype
Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M.
Genotype
Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M.
Genotype
Darabi, Hatef, Beesley, Jonathan, Droit, Arnaud, Kar, Siddhartha, Nord, Silje, Moradi Marjaneh, Mahdi, Soucy, Penny, Michailidou, Kyriaki, Ghoussaini, Maya, Fues Wahl, Hanna, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Choi, Ji-Yeob, Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Devilee, Peter, Dörk, Thilo, Easton, Douglas F., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hartman, Mikael, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Kang, Daehee, Khan, Sofia, Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Lambrechts, Diether, Le Marchand, Loic, Lee, Soo Chin, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mayes, Rebecca, McKay, James, Meindl, Alfons, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olswold, Curtis, Orr, Nick, Peterlongo, Paolo, Pita, Guillermo, Pylkäs, Katri, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Stram, Daniel O., Surowy, Harald, Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine M., Vincent, Daniel, Winqvist, Robert, Wu, Anna H., Wu, Pei-Ei, Yip, Cheng Har, Zheng, Wei, Pharoah, Paul D. P., Hall, Per, Edwards, Stacey L., Simard, Jacques, French, Juliet D., Chenevix-Trench, Georgia, Dunning, Alison M.