Genetic variation
rs2275913
Overview
SNPs are specific locations in the DNA where genetic variations can occur. Every person has a unique composition of variations.
SNP rs2275913 is located on chromosome 6. The most common variation at this position is the G. People with other variations might have letter A instead.
Since humans have each twice (one from each parent), these letter-variations occur on both chromosomes. People can have the same or different letters on both chromosomes. Every person's individual variation assembly is referred to as genotype. For SNP rs2275913 there are 3 currently known genotypes: A/G , G/G or A/A
Genome Browser
This interactive browser visualizes what no human can see with the naked eye - our DNA. From a down to a specific position on a . The position you are looking at here is the exact location of SNP rs2275913. Explore more SNPs and their effects on the body by browsing left and right along the DNA strand.
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Mitochondrial DNAEffects relating to rs2275913
Your genetic code influences you in many ways. This may be by either causing you to have a specific trait (eg. Eye colour) or your risk of developing a specific disease.
Each combination of genetic letters (called bases) is called a genotype for this specific SNP. Each Genotype can have a different effect on your body. The table below shows which genotype causes which traits or disease risks.
Current research shows 6 disease risks associated with rs2275913. The following table shows the relationship between genotype and .
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Ulcerative colitis (UC) | 0.45x | ||
Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie Text Extract:The IL17A rs2275913 variant allele frequency distribution in patients with severe UC was significantly different from that in the controls (P=0.024, OR=0.45, 95% CI=0.210.91, Table 3) PMCID: PMCID3439435 | |||
| Colorectal cancer (CRC) | 3.75x | ||
IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien Text Extract:We also observed that similar to the rs2275913 genotypes, the distribution of allelic frequencies in CRCs was significantly different than in healthy controls (OR = 2.038, 2 = 9.76, p = 0.00179) PMCID: PMCID6130533 | |||
| Cardiomyopathy | 1.20x | ||
Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations (2020) Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert Text Extract:As can be observed in Table4 the IL17A rs2275913 allele effect was consistent in the Colombian, Argentinian and Brazilian cohorts, and the association with chronic cardiomyopathy susceptibility improved after the meta-analysis showing nominally statistical differences (P=0.040, OR=1.20, 95% CI=1.011.45, under a fixed-effects meta-analysis) PMCID: PMCID7081280 | |||
| Lack of multifocality | 0.19x | ||
Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population. (2015) Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu Text Extract:Interestingly, the IL17A SNP rs2275913 (codominant model 2, OR=0.19, P=0.034) was significantly associated with lack of multifocality PMID: PMID25484349 | |||
| Henoch-Schönlein purpura (HSP) | 0.70x | ||
Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. (2017) Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui Text Extract:Compared to the healthy controls, the IL17A rs2275913 variant allele A showed a significant association with HSP [odds ratio (OR) 0.70; 95 % CI 0.51-0.94, P = 0.018] PMID: PMID27021337 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Ulcerative colitis (UC) | 1.00x | ||
Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie Text Extract:The IL17A rs2275913 variant allele frequency distribution in patients with severe UC was significantly different from that in the controls (P=0.024, OR=0.45, 95% CI=0.210.91, Table 3) PMCID: PMCID3439435 | |||
| Colorectal cancer (CRC) | 1.00x | ||
IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien Text Extract:We also observed that similar to the rs2275913 genotypes, the distribution of allelic frequencies in CRCs was significantly different than in healthy controls (OR = 2.038, 2 = 9.76, p = 0.00179) PMCID: PMCID6130533 | |||
| Cardiomyopathy | 1.00x | ||
Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations (2020) Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert Text Extract:As can be observed in Table4 the IL17A rs2275913 allele effect was consistent in the Colombian, Argentinian and Brazilian cohorts, and the association with chronic cardiomyopathy susceptibility improved after the meta-analysis showing nominally statistical differences (P=0.040, OR=1.20, 95% CI=1.011.45, under a fixed-effects meta-analysis) PMCID: PMCID7081280 | |||
| Chronic obstructive pulmonary disease (COPD) | 2.27x | ||
Genetic variants in IL17A and serum levels of IL-17A are associated with COPD related to tobacco smoking and biomass burning (2020) Ponce-Gallegos, Marco A., Pérez-Rubio, Gloria, Ambrocio-Ortiz, Enrique, Partida-Zavala, Neftali, Hernández-Zenteno, Rafael, Flores-Trujillo, Fernando, García-Gómez, Leonor, Hernández-Pérez, Andrea, Ramírez-Venegas, Alejandra, Falfán-Valencia, Ramcés Text Extract:In the co-dominant model, a statistically significant difference was found for the AA genotype of rs2275913 when comparing COPD-S vs. HS (p<0.01; OR=3.53) PMCID: PMCID6972744 | |||
| Lack of multifocality | 1.00x | ||
Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population. (2015) Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu Text Extract:Interestingly, the IL17A SNP rs2275913 (codominant model 2, OR=0.19, P=0.034) was significantly associated with lack of multifocality PMID: PMID25484349 | |||
| Henoch-Schönlein purpura (HSP) | 1.00x | ||
Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. (2017) Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui Text Extract:Compared to the healthy controls, the IL17A rs2275913 variant allele A showed a significant association with HSP [odds ratio (OR) 0.70; 95 % CI 0.51-0.94, P = 0.018] PMID: PMID27021337 | |||
Genotype
| Effect | Likelihood | Level of evidence | Research |
|---|---|---|---|
| Ulcerative colitis (UC) | 0.20x | ||
Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie Text Extract:The IL17A rs2275913 variant allele frequency distribution in patients with severe UC was significantly different from that in the controls (P=0.024, OR=0.45, 95% CI=0.210.91, Table 3) PMCID: PMCID3439435 | |||
| Colorectal cancer (CRC) | 6.49x | ||
IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien Text Extract:We also observed that similar to the rs2275913 genotypes, the distribution of allelic frequencies in CRCs was significantly different than in healthy controls (OR = 2.038, 2 = 9.76, p = 0.00179) PMCID: PMCID6130533 | |||
| Cardiomyopathy | 1.40x | ||
Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations (2020) Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert Text Extract:As can be observed in Table4 the IL17A rs2275913 allele effect was consistent in the Colombian, Argentinian and Brazilian cohorts, and the association with chronic cardiomyopathy susceptibility improved after the meta-analysis showing nominally statistical differences (P=0.040, OR=1.20, 95% CI=1.011.45, under a fixed-effects meta-analysis) PMCID: PMCID7081280 | |||
| Chronic obstructive pulmonary disease (COPD) | 3.53x | ||
Genetic variants in IL17A and serum levels of IL-17A are associated with COPD related to tobacco smoking and biomass burning (2020) Ponce-Gallegos, Marco A., Pérez-Rubio, Gloria, Ambrocio-Ortiz, Enrique, Partida-Zavala, Neftali, Hernández-Zenteno, Rafael, Flores-Trujillo, Fernando, García-Gómez, Leonor, Hernández-Pérez, Andrea, Ramírez-Venegas, Alejandra, Falfán-Valencia, Ramcés Text Extract:In the co-dominant model, a statistically significant difference was found for the AA genotype of rs2275913 when comparing COPD-S vs. HS (p<0.01; OR=3.53) PMCID: PMCID6972744 | |||
| Lack of multifocality | 0.04x | ||
Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population. (2015) Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu Text Extract:Interestingly, the IL17A SNP rs2275913 (codominant model 2, OR=0.19, P=0.034) was significantly associated with lack of multifocality PMID: PMID25484349 | |||
| Henoch-Schönlein purpura (HSP) | 0.49x | ||
Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. (2017) Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui Text Extract:Compared to the healthy controls, the IL17A rs2275913 variant allele A showed a significant association with HSP [odds ratio (OR) 0.70; 95 % CI 0.51-0.94, P = 0.018] PMID: PMID27021337 | |||
Distribution
Knowing your genome can actually tell you a lot about your ancestors.
The prevalence of the different genotypes is based on the native inhabitants of a region. In the map below you see how common each genotype is in the native inhabitants of those regions. Since genetic material is passed down form generation to generation, your DNA shows traces of the geographical origins of your ancestors.
This data is based on “The 1000 Genomes Project” which established one of the most detailed overviews of human genetic variations across the globe. The regions are broadly categorized into five continental groups: Africa, America, Europe, South Asia and East Asia. All continental groups together display the global prevalence. Click through the regions, to learn more about the local prevalence of the possible genotypes.
At present, there is no distribution data available for SNP rs2275913.
Studies and sources
All of the resources below examine SNP rs2275913
Genotype
Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie
Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien
Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert
Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu
Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui
Genotype
Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie
Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien
Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert
Ponce-Gallegos, Marco A., Pérez-Rubio, Gloria, Ambrocio-Ortiz, Enrique, Partida-Zavala, Neftali, Hernández-Zenteno, Rafael, Flores-Trujillo, Fernando, García-Gómez, Leonor, Hernández-Pérez, Andrea, Ramírez-Venegas, Alejandra, Falfán-Valencia, Ramcés
Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu
Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui
Genotype
Yu, Pengli, Shen, Fangcheng, Zhang, Xiaofei, Cao, Risheng, Zhao, Xiaodan, Liu, Pengfei, Tu, Huiming, Yang, Xiaozhong, Shi, Ruihua, Zhang, Hongjie
Al Obeed, Omar A, Vaali-Mohamed, Mansoor-Ali, Alkhayal, Khayal A, Bin Traiki, Thamer A, Zubaidi, Ahmad M, Arafah, Maha, Harris, Robert A, Khan, Zahid, Abdulla, Maha-Hamadien
Strauss, Mariana, Palma-Vega, Miriam, Casares-Marfil, Desiré, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Paglini, Patricia A., Paglini, Patricia A., Schijman, Alejandro G., Robello, Carlos, Echeverría, Luis E., Vargas-Alarcón, Gilberto, Calzada, José E., Fernández-Mestre, Mercedes, Fresno, Manuel, Pinazo, Maria Jesus, Martín, Javier, Acosta-Herrera, Marialbert
Ponce-Gallegos, Marco A., Pérez-Rubio, Gloria, Ambrocio-Ortiz, Enrique, Partida-Zavala, Neftali, Hernández-Zenteno, Rafael, Flores-Trujillo, Fernando, García-Gómez, Leonor, Hernández-Pérez, Andrea, Ramírez-Venegas, Alejandra, Falfán-Valencia, Ramcés
Lee, Young Chan, Chung, Joo-Ho, Kim, Su Kang, Rhee, Sang Youl, Chon, Suk, Oh, Seung Joon, Hong, Il Ki, Eun, Young Gyu
Xu, Hui, Pan, Yanxiang, Li, Wei, Fu, Haidong, Zhang, Junfeng, Shen, Hongqiang, Han, Xiucui