SLCO1B1*32 is a specific haplotype found on the solute carrier organic anion transporter family member 1B1 gene.  This haplotype is intricately connected to 26 specific variants. It plays a significant role in how individuals metabolize certain drugs, especially rifampin, lovastatin, simvastatin, repaglinide. SLCO1B1*32 has a Haplotype Performance of 100%. The combined haplotype performances of two haplotypes and individual posseses on solute carrier organic anion transporter family member 1B1 determines the overall gene performance. The gene performance indicates the metabolism rate, classifying individuals as either poor, intermediate, extensive, or ultrarapid metabolizers. This has a direct influence on how they process certain drugs.

Role of the Gene that carries the Haplotype SLCO1B1*32

The gene solute carrier organic anion transporter family member 1B1, plays a crucial role in the way our body processes fat by breaking it down and managing its levels. This occurs mostly in the liver, an essential organ for maintaining healthy body functions. The gene can lead to a change in the protein structure, potentially causing inefficient breakdown of fat. This may contribute to an increased risk of developing liver-related health issues such as fatty liver disease. While genetics play a part, maintaining a healthy lifestyle can help minimize these risks.

SLCO1B1*32

% Haplotype Performance:

100%

This is the standard or typical haplotype performance. The haplotype performance is at a "normal" level.

The haplotype performances of two haplotypes an individual possess on solute carrier organic anion transporter family member 1B1 determines their overall gene performance.

100% Haplotype Performance

The haplotype performance of a haplotype, when considering drug metabolization, provides a quantifiable measure of how effectively a person's genetics might influence their ability to metabolize or break down specific drugs. The combined effect of the two haplotypes you possess (i.e., the two sets of variants) will determine your overall gene performance related to drug metabolism.

Set of variants that define SLCO1B1*32

Haplotypes are linked to multiple variants, and each variant in the haplotype has a specific allele.

there are 26 Variants linked to SLCO1B1*32 in the databse:

SLCO1B1*32

Variant
Allele
Summary

rs2306282

A

rs2306282 is a genetic variant on gene SLCO1B1.

rs2306283

G

rs2306283 is a genetic variant on gene SLCO1B1.

rs4149056

T

rs4149056 is a genetic variant on gene SLCO1B1.

rs11045819

A

rs11045819 is a genetic variant on gene SLCO1B1.

rs11045852

G

rs11045852 is a genetic variant on gene SLCO1B1.

rs11045853

G

rs11045853 is a genetic variant on gene SLCO1B1.

rs34671512

A

rs34671512 is a genetic variant on gene SLCO1B1.

rs55737008

A

rs55737008 is a genetic variant on gene SLCO1B1.

rs55901008

T

rs55901008 is a genetic variant on gene SLCO1B1.

rs56061388

T

rs56061388 is a genetic variant on gene SLCO1B1.

rs56101265

T

rs56101265 is a genetic variant on gene SLCO1B1.

rs56199088

A

rs56199088 is a genetic variant on gene SLCO1B1.

rs56387224

A

rs56387224 is a genetic variant on gene SLCO1B1.

rs59113707

C

rs59113707 is a genetic variant on gene SLCO1B1.

rs59502379

G

rs59502379 is a genetic variant on gene SLCO1B1.

rs71581941

C

rs71581941 is a genetic variant on gene SLCO1B1.

rs72559745

A

rs72559745 is a genetic variant on gene SLCO1B1.

rs72559747

C

rs72559747 is a genetic variant on gene SLCO1B1.

rs72559748

A

rs72559748 is a genetic variant on gene SLCO1B1.

rs74064213

A

rs74064213 is a genetic variant on gene SLCO1B1.

rs77271279

G

rs77271279 is a genetic variant.

rs79135870

A

rs79135870 is a genetic variant on gene SLCO1B1.

rs139257324

C

rs139257324 is a genetic variant on gene SLCO1B1.

rs142965323

G

rs142965323 is a genetic variant on gene SLCO1B1.

rs183501729

C

rs183501729 is a genetic variant on gene SLCO1B1.

rs200995543

C

rs200995543 is a genetic variant on gene SLCO1B1.

SLCO1B1*32

Name

rs2306282

Allele

A

Summary

rs2306282 is a genetic variant on gene SLCO1B1.

Name

rs2306283

Allele

G

Summary

rs2306283 is a genetic variant on gene SLCO1B1.

Name

rs4149056

Allele

T

Summary

rs4149056 is a genetic variant on gene SLCO1B1.

Name

rs11045819

Allele

A

Summary

rs11045819 is a genetic variant on gene SLCO1B1.

Name

rs11045852

Allele

G

Summary

rs11045852 is a genetic variant on gene SLCO1B1.

Name

rs11045853

Allele

G

Summary

rs11045853 is a genetic variant on gene SLCO1B1.

Name

rs34671512

Allele

A

Summary

rs34671512 is a genetic variant on gene SLCO1B1.

Name

rs55737008

Allele

A

Summary

rs55737008 is a genetic variant on gene SLCO1B1.

Name

rs55901008

Allele

T

Summary

rs55901008 is a genetic variant on gene SLCO1B1.

Name

rs56061388

Allele

T

Summary

rs56061388 is a genetic variant on gene SLCO1B1.

Name

rs56101265

Allele

T

Summary

rs56101265 is a genetic variant on gene SLCO1B1.

Name

rs56199088

Allele

A

Summary

rs56199088 is a genetic variant on gene SLCO1B1.

Name

rs56387224

Allele

A

Summary

rs56387224 is a genetic variant on gene SLCO1B1.

Name

rs59113707

Allele

C

Summary

rs59113707 is a genetic variant on gene SLCO1B1.

Name

rs59502379

Allele

G

Summary

rs59502379 is a genetic variant on gene SLCO1B1.

Name

rs71581941

Allele

C

Summary

rs71581941 is a genetic variant on gene SLCO1B1.

Name

rs72559745

Allele

A

Summary

rs72559745 is a genetic variant on gene SLCO1B1.

Name

rs72559747

Allele

C

Summary

rs72559747 is a genetic variant on gene SLCO1B1.

Name

rs72559748

Allele

A

Summary

rs72559748 is a genetic variant on gene SLCO1B1.

Name

rs74064213

Allele

A

Summary

rs74064213 is a genetic variant on gene SLCO1B1.

Name

rs77271279

Allele

G

Summary

rs77271279 is a genetic variant.

Name

rs79135870

Allele

A

Summary

rs79135870 is a genetic variant on gene SLCO1B1.

Name

rs139257324

Allele

C

Summary

rs139257324 is a genetic variant on gene SLCO1B1.

Name

rs142965323

Allele

G

Summary

rs142965323 is a genetic variant on gene SLCO1B1.

Name

rs183501729

Allele

C

Summary

rs183501729 is a genetic variant on gene SLCO1B1.

Name

rs200995543

Allele

C

Summary

rs200995543 is a genetic variant on gene SLCO1B1.

Did you know that haplotypes play a major role in pharmacogenetics?

Certain haplotypes in combination can influence how a person's body metabolizes drugs. This is because these haplotypes can affect the function of enzymes responsible for drug metabolism. A change or variation in the DNA sequence of a gene that codes for a drug-metabolizing enzyme can increase or decrease the activity of that enzyme.

Based on the activity of these enzymes (influenced by haplotypes), individuals can be classified into different metabolizer categories:

  1. Poor Metabolizers (PMs): These individuals have little or no enzyme activity due to certain genetic variations. As a result, they might not metabolize certain drugs efficiently, leading to a higher risk of side effects because the drug remains in their system for a longer time.
  2. Intermediate Metabolizers (IMs): These people have reduced enzyme activity. They metabolize drugs slower than normal metabolizers but faster than poor metabolizers.
  3. Extensive Metabolizers (EMs): This is the "standard" or "expected" rate of metabolization. Drugs are metabolized at a regular rate, leading to expected drug efficacy and side effects.
  4. Ultrarapid Metabolizers (UMs): These individuals have increased enzyme activity. They break down certain drugs very quickly, which can decrease the effectiveness of the drug because it's cleared from their system too rapidly.

In conclusion, understanding one's haplotype and consequent metabolizer status can be crucial for personalized medicine. It can provide guidance on drug selection and dosing to optimize therapeutic outcomes and minimize adverse reactions.

Dr. Wallerstorfer Dr. Wallerstorfer

Pharmacogenetics

The SLCO1B1*32 haplotype is linked to the SLCO1B1 gene, a key component in the body's drug-processing system. This gene provides the blueprint for an enzyme pivotal in breaking down a range of medicines. The presence of the SLCO1B1*32 haplotype can influence the efficiency of this enzyme. Based on its activity score, individuals with this haplotype might be classified as poor, intermediate, normal, or ultrarapid metabolizers. This classification is vital as it dictates how rapidly one processes certain medications, potentially impacting the drug's efficacy and risk of side effects. Recognizing the presence of SLCO1B1*32 in an individual can guide healthcare professionals in tailoring medication doses to achieve optimal therapeutic outcomes.

there are 16 Drugs associated with 16 Variants that are located on SLCO1B1

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